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Journal of Dental Research
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The Junctional Epithelium around Murine Teeth differs from Gingival Epithelium in its Basement Membrane Composition

J. Oksanen

University of Turku, Institute of Dentistry, FIN-20520 Turku, Finland

L.M. Sorokin

Interdisciplinary Center for Clinical Research, Nikolaus Fibieger Center, Erlangen, Germany

I. Virtanen

Institute of Biomedicine, Department of Anatomy, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FIN-00014 University of Helsinki, Helsinki, Finland

M. Hormia

University of Turku, Institute of Dentistry, FIN-20520 Turku, Finland, Institute of Biomedicine, Department of Anatomy, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FIN-00014 University of Helsinki, Helsinki, Finland, marketta.hormia{at}helsinki.fi

It is not known whether epithelial differentiation patterns are reflected in the composition of gingival basement membranes (BMs). We have investigated the expression of laminin isoforms and associated BM components in the murine dento-epithelial junction by using immunofluorescence microscopy. Our results show that chains of laminins 5/6/7/10/11 are expressed in the BM of outer gingival epithelium. The external BM between junctional epithelium (JE) and connective tissue differs from gingival BM by lacking laminin-7 and -11 chains. The internal basal lamina (IBL) between JE and tooth contains only laminin-5. Collagen chains {alpha}1,2(IV) and nidogen-1 are present in other BMs except the IBL. The dento-epithelial junction thus has a unique BM composition, suggesting that epithelial cells are able to secrete two extracellular matrices in a polarized manner. The exclusive expression of the non-self-polymerizing laminin-5 indicates that the IBL is not a BM by definition, but rather a simple extracellular matrix lacking network structure.

Key Words: gingiva • laminin • junctional epithelium • basement membrane

Journal of Dental Research, Vol. 80, No. 12, 2093-2097 (2001)
DOI: 10.1177/00220345010800121401
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D.D. Bosshardt and N.P. Lang
The Junctional Epithelium: from Health to Disease
Journal of Dental Research, January 1, 2005; 84(1): 9 - 20.
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