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Journal of Dental Research
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Experimental Gingivitis in Women Using Oral Contraceptives

P.M. Preshaw

University of Newcastle upon Tyne, The Dental School, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK

M.A. Knutsen

Ohio State University, Department of Primary Care, College of Dentistry, 305 West 12th Ave., PO Box 182357, Columbus, OH 43218, USA

A. Mariotti

Ohio State University, Department of Periodontology, College of Dentistry, Department of Pharmacology, College of Medicine, 305 West 12th Ave, PO Box 182357, Columbus, OH 43218-2357, USA

Oral contraceptives (OC) have historically been considered a risk factor for gingival diseases. We set out to investigate this premise further, given that, over recent years, hormone concentrations in OC have been substantially reduced. Using a prospective, split-mouth, experimental gingivitis model, pre-menopausal women either taking (n = 14) or not taking (n = 16) OC refrained from all oral hygiene practices in one maxillary (test) quadrant while continuing to perform normal oral hygiene activities in the contralateral (control) quadrant. Mean increases in plaque index (PI), gingival index (GI), and gingival crevicular fluid (GCF) volume from days 0 to 21 were significant in test quadrants (P < 0.05) but did not differ regardless of whether subjects received OC (P > 0.05). PI, GI, and GCF volume did not vary in control quadrants over the course of the study (P > 0.05). Analysis of these data suggests that current OC formulations do not affect the inflammatory response of the gingiva to dental plaque.

Key Words: gingival disease • experimental gingivitis • oral contraceptives • inflammation

Journal of Dental Research, Vol. 80, No. 11, 2011-2015 (2001)
DOI: 10.1177/00220345010800111201
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