This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Stenudd, C. Articles by Strömberg, N. Search for Related Content PubMed PubMed Citation Articles by Stenudd, C. Articles by Strömberg, N. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?

The Association of Bacterial Adhesion with Dental Caries

Departments of Odontology/Cariology, Umea University, SE-901 87 Umea, Sweden

A. Nordlund

Departments of Odontology/Cariology, Umea University, SE-901 87 Umea, Sweden

M. Ryberg

Departments of Odontology/Cariology, Umea University, SE-901 87 Umea, Sweden

I. Johansson

Departments of Odontology/Cariology, Umea University, SE-901 87 Umea, Sweden

C. KallestÅl

Departments of Odontology/Cariology, Umea University, SE-901 87 Umea, Sweden, Department of Public Health and Clinical Medicine/Epidemiology, Umea University, SE-901 87 Umea, Sweden

N. Strömberg

Departments of Odontology/Cariology, Umea University, SE-901 87 Umea, Sweden

Saliva adhesion of bacteria is a key event in oral biofilm formation. Here, we used partial least-squares (PLS) analysis to correlate adhesion of cariogenic (Streptococcus mutans Ingbritt) and commensal (Actinomyces naeslundii LY7) model bacteria, and their agglutinin and acidic proline-rich protein ligands, respectively, with high and low caries experiences in 38 children reflecting today's skewed caries distribution. Adhesion of S. mutans was among the factors correlating strongest with high caries experience when PLS modeled together with traditional factors (e.g., sugar intake, lactobacilli counts). Saliva phenotypes with high agglutinin levels and Db-s (an acidic PRP variant) coincided with both high caries experience and S. mutans adhesion. A. naeslundii adhesion correlated with low caries experience. Non-Db phenotypes (i.e., acidic PRP-1 and PRP-2 variants) coincided with both low caries experience and S. mutans, but high A. naeslundii, adhesion. Thus, bacterial adhesion may modulate susceptibility and resistance to dental caries.

Key Words: acidic proline-rich proteins • agglutinins • bacterial adhesion • dental caries susceptibility.

Journal of Dental Research, Vol. 80, No. 11, 2005-2010 (2001)
DOI: 10.1177/00220345010800111101


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Drobni, T. Li, C. Kruger, V. Loimaranta, M. Kilian, L. Hammarstrom, H. Jornvall, T. Bergman, and N. Stromberg Host-Derived Pentapeptide Affecting Adhesion, Proliferation, and Local pH in Biofilm Communities Composed of Streptococcus and Actinomyces Species Infect. Immun., November 1, 2006; 74(11): 6293 - 6299. [Abstract] [Full Text] [PDF]

				M. Drobni, I.-M. Olsson, C. Eriksson, F. Almqvist, and N. Stromberg Multivariate Design and Evaluation of a Set of RGRPQ-derived Innate Immunity Peptides J. Biol. Chem., June 2, 2006; 281(22): 15164 - 15171. [Abstract] [Full Text] [PDF]

				R.P. Allaker and D. Dymock Proceedings of the 8th European Oral Microbiology Workshop Advances in Dental Research, November 1, 2005; 18(2): 27 - 33. [Full Text] [PDF]

				M. Levine, W. L. Owen, and K. T. Avery Antibody Response to Actinomyces Antigen and Dental Caries Experience: Implications for Caries Susceptibility Clin. Vaccine Immunol., June 1, 2005; 12(6): 764 - 769. [Abstract] [Full Text] [PDF]

				V. Loimaranta, N. S. Jakubovics, J. Hytonen, J. Finne, H. F. Jenkinson, and N. Stromberg Fluid- or Surface-Phase Human Salivary Scavenger Protein gp340 Exposes Different Bacterial Recognition Properties Infect. Immun., April 1, 2005; 73(4): 2245 - 2252. [Abstract] [Full Text] [PDF]

				T. Oho, F. J. Bikker, A. V. Nieuw Amerongen, and J. Groenink A Peptide Domain of Bovine Milk Lactoferrin Inhibits the Interaction between Streptococcal Surface Protein Antigen and a Salivary Agglutinin Peptide Domain Infect. Immun., October 1, 2004; 72(10): 6181 - 6184. [Abstract] [Full Text] [PDF]

				F. J. Bikker, A. J. M. Ligtenberg, K. Nazmi, E. C. I. Veerman, W. van't Hof, J. G. M. Bolscher, A. Poustka, A. V. N. Amerongen, and J. Mollenhauer Identification of the Bacteria-binding Peptide Domain on Salivary Agglutinin (gp-340/DMBT1), a Member of the Scavenger Receptor Cysteine-rich Superfamily J. Biol. Chem., August 23, 2002; 277(35): 32109 - 32115. [Abstract] [Full Text] [PDF]