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Journal of Dental Research
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Crown Morphology and Pattern of Odontoblast Differentiation in Lower Molars of Tabby Mice

S. Lisi

INSERM U424, Institut de Biologie Medicale, Faculty of Medicine, 11, rue Humann, 67085 Strasbourg France

R. Peterková

Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic

P. Kristenová

Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic

J.L. Vonesch

Institut de Génétique et de Biologie Moleculaire et Cellulaire, Illkirch, France

M. Peterka

Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic

H. Lesot

INSERM U424, Institut de Biologie Medicale, Faculty of Medicine, 11, rue Humann, 67085 Strasbourg France

The Tabby mutation leads to abnormal crown morphology in the developing molars. To identify cusps which were altered in number, size, and position in the first lower molars of mutant mice, we analyzed the patterning of odontoblast differentiation using morphological criteria on serial sections and 3D reconstructions. In wild-type mice, polarized and functional odontoblasts were first observed in the median L2 and B2 cusps, then in the distal cusps L3 and B3, and finally in L1, B1, and 4. In Tabby mice, terminal differentiation of odontoblasts was retarded by 24-36 hours compared with wild-type mice. Polarized odontoblasts first appeared in the most mesial part of the tooth and progressively extended distally. The mesial part of the M1 in Tabby fetuses may correspond to the L2, B2 area from wild-type mice. The ante-molar dental primordium observed in some samples would thus represent remnants of cusps L1 and B1.

Key Words: odontoblast • morphology • tabby

Journal of Dental Research, Vol. 80, No. 11, 1980-1983 (2001)
DOI: 10.1177/00220345010800110601
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