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Journal of Dental Research
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A New Approach to Enhancement of Bone Formation by Electrically Polarized Hydroxyapatite

N.C. Teng

Division of Developmental Oral Health Sciences, Graduate School, Department of Inorganic Materials, Division of Biomaterials, Institute of Biomaterials and Bioengineering

S. Nakamura

Department of Inorganic Materials, Division of Biomaterials, Institute of Biomaterials and Bioengineering

Y. Takagi

Division of Developmental Oral Health Sciences, Graduate School

Y. Yamashita

Division of Maxillofacial/Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549 Japan

M. Ohgaki

Department of Inorganic Materials, Division of Biomaterials, Institute of Biomaterials and Bioengineering

K. Yamashita

Department of Inorganic Materials, Division of Biomaterials, Institute of Biomaterials and Bioengineering

An electrical field may affect osteogenesis. Since we found that hydroxyapatite (HA) ceramics may be polarizable, we hypothesized that electrically polarized HA may foster production of new bone in vivo. Both polarized and non-polarized HA ceramics were inserted into the subperiosteum spaces at the parietal bone area of rats. After 2, 4, and 8 weeks, the implant sites were examined histologically. Morphometric analysis revealed that new bone formation was accelerated on the negatively charged surface of the polarized HA (N-surface) at 2 weeks. The newly formed bone approached maturation at 4 weeks and was thicker on the N-surface than in the controls. By 8 weeks, newly formed bone in the controls was almost the same as that on the N-surface. These findings suggest that polarized HA is biocompatible and that bone formation on the N-surface is enhanced in the early stage of bone healing.

Key Words: electrically polarized • hydroxyapatite • bone formation • rats.

Journal of Dental Research, Vol. 80, No. 10, 1925-1929 (2001)
DOI: 10.1177/00220345010800101201
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