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Journal of Dental Research
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Cloning, Characterization, and Tissue Expression Pattern of Mouse Nma/BAMBI During Odontogenesis

C. Knight

University of Texas Health Science Center at San Antonio, Dental School, Department of Pediatric Dentistry

D. Simmons

University of Texas Health Science Center at San Antonio, Dental School, Department of Pediatric Dentistry

T.T. Gu

University of Texas Health Science Center at San Antonio, Dental School, Department of Pediatric Dentistry

J. Gluhak-Heinrich

Department of Orthodontics, 7703 Floyd Curl Drive, MCS 7888, San Antonio, TX 78229-3900

D. Pavlin

Department of Orthodontics, 7703 Floyd Curl Drive, MCS 7888, San Antonio, TX 78229-3900

M. Zeichner-David

Center for Craniofacial Molecular Biology, University of Southern California, School of Dentistry, Los Angeles, CA

M. MacDougall

University of Texas Health Science Center at San Antonio, Dental School, Department of Pediatric Dentistry

Degenerate oligonucleotides to consensus serine kinase functional domains previously identified a novel, partial rabbit tooth cDNA (Zeichner-David et al., 1992) that was used in this study to identify a full-length mouse clone. A 1390-base-pair cDNA clone was isolated encoding a putative 260-amino-acid open reading frame containing a hydrophobic 25-amino-acid potential transmembrane domain. This clone shares some homology with the TGF-β type I receptor family, but lacks the intracellular kinase domain. DNA database analysis revealed that this clone has 86% identity to a newly isolated human gene termed non-metastatic gene A and 80% identity to a Xenopus cDNA clone termed BMP and activin membrane bound inhibitor. Here we report the mouse Nma/BAMBI cDNA sequence, the tissue expression pattern, and confirmed expression in dental cell lines. This study demonstrates that Nma/BAMBI is a highly conserved protein across species and is expressed at high levels during odontogenesis.

Key Words: Nma • BAMBI • transmembrane protein • odontogenesis • epithelial-mesenchymal interactions

Journal of Dental Research, Vol. 80, No. 10, 1895-1902 (2001)
DOI: 10.1177/00220345010800100701
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