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Immunodominant Region of Actinobacillus actinomycetemcomitans 40-kilodalton Heat Shock Protein in Patients with Rheumatoid Arthritis

Department of Oral and Maxillofacial Oncology, Kyushu University, Faculty of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, Department of Preventive Dentistry, Kyushu University, Faculty of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, aki{at}dent.kyushu-u.ac.jp

Y. Nakano

Department of Preventive Dentistry, Kyushu University, Faculty of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Y. Yamashita

Department of Preventive Dentistry, Kyushu University, Faculty of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

T. Oho

Department of Preventive Dentistry, Kyushu University, Faculty of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

H. Ito

Department of Preventive Dentistry, Faculty of Dentistry, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

M. Kondo

Division of Rheumatic Disease, Department of Orthopedic Surgery, National Kyushu Medical Center Hospital, 1-8-1 Jigyohama, Chuo-ku, Fukuoka 810-8563, Japan

M. Ohishi

Department of Oral and Maxillofacial Oncology, Kyushu University, Faculty of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

T. Koga

Department of Preventive Dentistry, Kyushu University, Faculty of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Bacterial heat shock proteins have been implicated in the pathogenesis of several diseases, and the immunological relationship between rheumatoid arthritis (RA) and Escherichia coli DnaJ has been reported. Since there are similarities in the tissue destruction process of RA and periodontitis, we examined the reactivities of antibodies in sera from RA patients to the DnaJ protein from Actinobacillus actinomycetemcomitans. An enzyme-linked immunosorbent assay showed that IgG titers to the N-terminal conservative region of the DnaJ are significantly higher in RA patients compared with the healthy controls (p < 0.05). Furthermore, we examined IgG titers of disease controls to determine the specificity of the immune responses to this region in RA patients. The difference between RA and infectious disease patients was also significant (p < 0.05). These results suggest that the N-terminal region of DnaJ from A. actinomycetemcomitans may contribute to the etiologic analysis of RA.

Key Words: Actinobacillus actinomycetemcomitans • DnaJ • heat shock protein (HSP) • periodontitis • rheumatoid arthritis (RA).

Journal of Dental Research, Vol. 80, No. 1, 346-350 (2001)
DOI: 10.1177/00220345010800010901


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