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Journal of Dental Research
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Meal Pattern Analysis in Response to Temporomandibular Joint Inflammation in the Rat

R.P. Harper

Departments of Biomedical Sciences, Department of Oral and Maxillofacial Surgery and Pharmacology

C.A. Kerins

Departments of Biomedical Sciences

R. Talwar

Departments of Biomedical Sciences, Department of Oral and Maxillofacial Surgery and Pharmacology

R. Spears

Departments of Biomedical Sciences

B. Hutchins

Departments of Biomedical Sciences

D.S. Carlson

Departments of Biomedical Sciences, Center for Craniofacial Research and Diagnosis, Baylor College of Dentistry, a member of the Texas A&M University System Health Science Center, 3302 Gaston Avenue, Dallas, Texas 75266-0677, USA

J.E. Mclntosh

Departments of Biomedical Sciences

L.L. Bellinger

Departments of Biomedical Sciences

Inflammation of the temporomandibular joint (TMJ) can alter behavioral responses such as food intake and mobilize stress hormones. The hypothesis of this study was that food intake and diurnal corticosterone analysis can be used as indicators of adjuvant-induced TMJ inflammation. Groups of rats received adjuvant or no injections at the beginning of the resting (AM) or activity (PM) phase. Forty-eight hours (early) or 6 weeks (late) after adjuvant injection, plasma corticosterone was assayed and food intake was recorded. Food intake was suppressed up to 4 days post-injection. As expected, the non-injected group showed low AM and high PM corticosterone. AM corticosterone was elevated, but PM corticosterone was attenuated in both early- and late-stage-injected rats. A computerized pair-fed experiment showed that adjuvant-induced hypophagia did not alter corticosterone levels. Meal pattern analysis revealed decreased food intake due to a decrease in the number of meals taken. Notably, meal size remained the same but meal duration increased. This model demonstrated that food intake and stress hormone analysis could be used as indicators for sequelae of adjuvant-induced TMJ inflammation.

Key Words: adjuvant • calcitonin gene-related peptide • feeding • diurnal rhythm • stress hormone.

Journal of Dental Research, Vol. 79, No. 9, 1704-1711 (2000)
DOI: 10.1177/00220345000790091101
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