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Cloning, Characterization, and Expression Analysis of Mouse Enamelysin

Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, 30 Convent Drive, MSC 4380, Bethesda, MD 20892-4380, USA, jc239h{at}nih.gov

J. Shi

Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, 30 Convent Drive, MSC 4380, Bethesda, MD 20892-4380, USA

X. Sun

department of Pediatric Dentistry, University of Texas Health Science Center at San Antonio, 78284, USA

Q. Qian

department of Pediatric Dentistry, University of Texas Health Science Center at San Antonio, 78284, USA

S. Yamada

Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, 30 Convent Drive, MSC 4380, Bethesda, MD 20892-4380, USA

Y. Liu

Craniofacial Development Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA

S. Krakora

Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, 30 Convent Drive, MSC 4380, Bethesda, MD 20892-4380, USA

J.D. Bartlett

Department of Biomineralization, Forsyth Institute, Boston, MA 02115, USA

Y. Yamada

Craniofacial Development Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA

J.A. Engler

department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 35294, USA

H. Birkedal-Hansen

Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, 30 Convent Drive, MSC 4380, Bethesda, MD 20892-4380, USA

J.P. Simmer

department of Pediatric Dentistry, University of Texas Health Science Center at San Antonio, 78284, USA

Enamelysin is a recently isolated member of the matrix metalloproteinase (MMP) family of extracellular matrix (ECM)-degrading enzymes. Here we describe the isolation and characterization of the mouse enamelysin cDNA. Expression of mouse enamelysin was detectable only in ameloblasts and odontoblasts of developing teeth. Characterization of mouse enamelysin demonstrated that it is highly conserved in both its sequence content and pattern of expression relative to the porcine, human, and bovine homologues previously described.

Key Words: MMP-20 • amelogenin • ameloblast • odontoblast.

Journal of Dental Research, Vol. 79, No. 9, 1697-1703 (2000)
DOI: 10.1177/00220345000790091001


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