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Journal of Dental Research
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AgNOR are Sensitive Markers of Radiation Lesions in Squamous Epithelia

M.V. lelmini

'Department of Radiobiology, National Atomic Energy Commission, Avenida del Libcrtador 8250, (1429) Buenos Aires, Faculty of Dentistry, University of Buenos Aires, M.T. dc Alvear 2142, Buenos Aires, Argentina

E. Heber

'Department of Radiobiology, National Atomic Energy Commission, Avenida del Libcrtador 8250, (1429) Buenos Aires

A.E. Schwint

'Department of Radiobiology, National Atomic Energy Commission, Avenida del Libcrtador 8250, (1429) Buenos Aires

R.L. Cabrini

'Department of Radiobiology, National Atomic Energy Commission, Avenida del Libcrtador 8250, (1429) Buenos Aires, Faculty of Dentistry, University of Buenos Aires, M.T. dc Alvear 2142, Buenos Aires, Argentina

M.E. Itoiz

'Department of Radiobiology, National Atomic Energy Commission, Avenida del Libcrtador 8250, (1429) Buenos Aires, Faculty of Dentistry, University of Buenos Aires, M.T. dc Alvear 2142, Buenos Aires, Argentina

The possibility of detection of incipient cellular alterations is central to early diagnosis and to clinician's capacity to discriminate between samples that appear similar on routine preparations. We examined the value of silver-stained nucleolar organizer regions (AgNOR) in detecting radio-induced alterations in a model of squamous epithelium biologically similar to oral mucosa. Morphometry of AgNOR has been proven to be of value in the detection of incipient cellular alterations. This method allows for the quantitative evaluation of lesions induced by high doses of radiation long before they become apparent in routine preparations. We herein examine the capacity of AgNOR to reveal the response to low doses of radiation, closer to the therapeutic or accidental dose to which the epithelium of oral mucosa may be exposed.

Key Words: AgNOR • nucleolar organizer regions • radiation • squamous epithelium.

Journal of Dental Research, Vol. 79, No. 3, 850-856 (2000)
DOI: 10.1177/00220345000790031101
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