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Journal of Dental Research
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The Chemical Composition of Tooth Enamel in Recessive Dystrophic Epidermolysis Bullosa: Significance with Respect to Dental Caries

J. Kirkham

to whom correspondence should be addressed

C. Robinson

Division of Oral Biology, Leeds Dental Institute, Clarendon Way, Leeds, LS2 9LU, UK

S.M. Strafford

Division of Oral Biology, Leeds Dental Institute, Clarendon Way, Leeds, LS2 9LU, UK

R.C. Shore

Division of Oral Biology, Leeds Dental Institute, Clarendon Way, Leeds, LS2 9LU, UK

W.A. Bonass

Division of Oral Biology, Leeds Dental Institute, Clarendon Way, Leeds, LS2 9LU, UK

S.J. Brookes

Division of Oral Biology, Leeds Dental Institute, Clarendon Way, Leeds, LS2 9LU, UK

J.T. Wright

Department of Pediatric Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this study was to characterize the enamel of teeth from patients suffering from recessive epidermolysis bullosa dystrophica (rEBD) in terms of its mineral content, carbonate content, protein content, and amino acid composition. The results showed that dental enamel from these patients was essentially normal in terms of its chemistry. It is therefore concluded that the high caries experience in recessive dystrophic epidermolysis bullosa patients is probably related to other factors, such as compromised oral hygiene and prolonged oral clearance due to extensive oral soft tissue damage and a cariogenic diet.

Key Words: enamel • caries • epidermolysis bullosa • mineral • Received August 24 • 1995 • Accepted March 27 • 1996

Journal of Dental Research, Vol. 75, No. 9, 1672-1678 (1996)
DOI: 10.1177/00220345960750090901
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