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Journal of Dental Research
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A Morphometric Investigation of Myotube Formation in Rabbit Embryo Medial Pterygoid Muscle

R. Benoît

Laboratoire d'Histologie, Faculte de Chirurgie Dentaire, Universite Rene-Descartes, Paris V, 1, rue Maurice Arnoux, 92120 Montrouge, France

C. Baudoin

Unité de Recherches Cliniques et Epidemiologiques, INSERM, U21-Villejuif, France

To determine the times of the appearance of myoblasts, early myotubes, late myotubes, and myofibers, we studied a region between two aponeuroses of the medial pterygoid masticatory muscle in embryos of two strains of rabbits, without disturbing the normal innervation. The objectives of this study were to define the quantitative relations among these cells and to determine their kinetics statistically. We used Fauve de Bourgogne and New Zealand rabbit embryos on day 17, day 17 plus 12 hours, day 18, day 18 plus 12 hours, and days 20, 22, and 28 of gestation. Cell proliferation was studied with a light microscope, by means of counting methods. Similar development was observed in the two strains of rabbits. The numbers of myoblasts decreased as follows: (i) a marked decrease; (ii) a sudden cessation of the decrease, marked by a rebound at 18 days, and lasting less than 24 hours; and (iii) a plateau between embryonic days 22 and 28. The onset of reduction in the number of early myotubes coincided with the rebound of myoblasts. The number of late myotubes increased at the time of maximal early myotube density and during rebound of the myoblasts. Myofiber densities were similar to late myotube densities on day 22. We suggest that early myotubes are formed very gradually by fusion of myoblasts, and that the significant increase in the numbers of myoblasts corresponds to the second generation of myoblasts necessary for differentiation of late myotubes. Key words: masticatory muscles, models, statistical, rabbits. Received April 18, 1994; Accepted May 30, 1996

Journal of Dental Research, Vol. 75, No. 11, 1835-1841 (1996)
DOI: 10.1177/00220345960750110401
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L. Zhang, Y. Yoshimura, T. Hatta, and H. Otani
Myogenic Determination and Differentiation of the Mouse Palatal Muscle in Relation to the Developing Mandibular Nerve
Journal of Dental Research, August 1, 1999; 78(8): 1417 - 1425.
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