Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Hietala, E.-L.
Right arrow Articles by Larmas, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hietala, E.-L.
Right arrow Articles by Larmas, M.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Diets
Hazardous Substances DB
*SUCROSE
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Evidence that High-sucrose Diet Reduces Dentin Formation and Disturbs Mineralization in Rat Molars

E.-L. Hietala

Institute of Dentistry, University of Oulu, Aapistie 3, FIN-90220 Oulu, Finland

M. Larmas

Institute of Dentistry, University of Oulu, Aapistie 3, FIN-90220 Oulu, Finland, Oulu University Hospital, Finland

In addition to its caries-promoting effect, a high-sucrose diet reduces the apposition of mineralized dentin in young rats. This study was undertaken to test whether it has a similar effect on the width of the as-yet-uncalcified matrix, predentin. Female Wistar rats were weaned at the age of 3 weeks and fed for 7 weeks with either a high-sucrose diet, a non-cariogenic raw potato starch diet, or a non-cariogenic commercial powdered rat food (for reference). The sucrose diet induced the greatest number of caries lesions. Dentin formation was smaller and the predentin zone wider in rats fed a sucrose diet when compared with rats fed the reference diet. In rats fed a starch diet, dentin formation was smaller than in rats fed a reference diet, but no alterations in the areas of caries lesions or predentin width were observed. Widening of the predentin zone in rats fed a high-sucrose diet may reflect changes in odontoblast function, such as reduced matrix synthesis and possibly disturbed mineralization. Dentinal caries progression may thus be modulated by odontoblast function, not as much by matrix formation but rather by mineralization.

Key Words: predentin • dentin • sucrose • starch • caries

Journal of Dental Research, Vol. 74, No. 12, 1899-1903 (1995)
DOI: 10.1177/00220345950740121401
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 ADRHome page
L. Tjaderhane, H. Palosaari, J. Wahlgren, M. Larmas, T. Sorsa, and T. Salo
Human Odontoblast Culture Method: The Expression of Collagen and Matrix Metalloproteinases (MMPs)
Advances in Dental Research, August 1, 2001; 15(1): 55 - 58.
[Abstract] [PDF]

Home page
 ADRHome page
L. Valikangas, E. Pekkala, M. Larmas, J. Risteli, T. Salo, and L. Tjaderhane
The Effects of High levels of Glucose and Insulin on Type I Collagen Synthesis in Mature Human Odontoblasts and Pulp Tissue in vitro
Advances in Dental Research, August 1, 2001; 15(1): 72 - 75.
[Abstract] [PDF]