Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Nakashima, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nakashima, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Induction of Dentin Formation on Canine Amputated Pulp by Recombinant Human Bone Morphogenetic Proteins (BMP)-2 and -4

M. Nakashima

Department of Conservative Dentistry, Faculty of Dentistry, Kyushu University, 61, Fukuoka 812, Japan

Dental pulp cells have the potential to differentiate into odontoblasts. The molecular mechanisms underlying differentiation are not clear. Demineralized dentin matrix is osteoinductive and contains bone morphogenetic protein (BMP) activity. BMPs have been implicated in embryonic odontogenic differentiation and hence may play a role in the differentiation of adult pulp cells into odontoblasts during pulpal healing. This study examined the hypothesis that BMPs induce dentin formation on amputated canine pulp. Recombinant human BMP-2 and BMP-4 were capped with inactivated dentin matrix on amputated pulp. At two months, the amputated pulp was filled with tubular dentin in the lower part and osteodentin in the upper part. The amount of dentin formed was markedly diminished when dentin matrix alone was implanted. These findings imply that recombinant human BMP-2 and BMP-4 induce differentiation of adult pulp cells into odontoblasts. Thus, BMPs may have a role in dentistry as a bioactive pulp-capping agent to induce dentin formation.

Key Words: Bone Morphogenetic Proteins-2 and -4 • Dentin • Dental Pulp • Odontoblasts • Differentiation • Dental Pulp Capping • Pulpotomy

Journal of Dental Research, Vol. 73, No. 9, 1515-1522 (1994)
DOI: 10.1177/00220345940730090601
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 CROBMHome page
M. Goldberg and A. J. Smith
CELLS AND EXTRACELLULAR MATRICES OF DENTIN AND PULP: A BIOLOGICAL BASIS FOR REPAIR AND TISSUE ENGINEERING
Critical Reviews in Oral Biology & Medicine, January 1, 2004; 15(1): 13 - 27.
[Abstract] [Full Text] [PDF]

Home page
 ADRHome page
A.J. Smith, P.E. Murray, A.J. Sloan, J.B. Matthews, and S. Zhao
Trans-dentinal Stimulation of Tertiary Dentinogenesis
Advances in Dental Research, August 1, 2001; 15(1): 51 - 54.
[Abstract] [PDF]

Home page
 ADRHome page
I. About and T. A. Mitsiadis
Molecular Aspects of Tooth Pathogenesis and Repair: in vivo and in vitro Models
Advances in Dental Research, August 1, 2001; 15(1): 59 - 62.
[Abstract] [PDF]

Home page
 ADRHome page
Y. Nakamura, L. Hammarstrom, E. Lundberg, H. Ekdahl, K. Matsumoto, S. Gestrelius, and S.P. Lyngstadaas
Enamel Matrix Derivative Promotes Reparative Processes in the Dental Pulp
Advances in Dental Research, August 1, 2001; 15(1): 105 - 107.
[Abstract] [PDF]

Home page
 ADRHome page
H. Lovschall, O. Fejerskov, and A. Flyvbjerg
Pulp-capping with Recombinant Human Insulin- like Growth Factor I (rhIGF-I) in Rat Molars
Advances in Dental Research, August 1, 2001; 15(1): 108 - 112.
[Abstract] [PDF]

Home page
 CROBMHome page
A.J. Smith and H. Lesot
Induction and Regulation of Crown Dentinogenesis: Embryonic Events as a Template for Dental Tissue Repair?
Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(5): 425 - 437.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Li, P. M. Bartold, C. Z. Zhang, R. W. Clarkson, W. G. Young, and M. J. Waters
Growth Hormone and Insulin-Like Growth Factor I Induce Bone Morphogenetic Proteins 2 and 4: A Mediator Role in Bone and Tooth Formation?
Endocrinology, September 1, 1998; 139(9): 3855 - 3862.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
M.N. Helder, H. Karg, T.J.M. Bervoets, S. Vukicevic, E.H. Burger, R.N. D'Souza, J.H.M. Woltgens, G. Karsenty, and A.L.J.J. Bronckers
Bone Morphogenetic Protein-7 (Osteogenic Protein-1, OP-1) and Tooth Development
Journal of Dental Research, April 1, 1998; 77(4): 545 - 554.
[Abstract] [PDF]

Home page
 JDRHome page
K. Yoshiba, N. Yoshiba, H. Nakamura, M. Iwaku, and H. Ozawa
Immunolocalization of Fibronectin during Reparative Dentinogenesis in Human Teeth after Pulp Capping with Calcium Hydroxide
Journal of Dental Research, August 1, 1996; 75(8): 1590 - 1597.
[Abstract] [PDF]

Home page
 JDRHome page
T. Zelles, K.R. Purushotham, S.P. Macauley, G.E. Oxford, and M.G. Humphreys-Beher
Concise Review: Saliva and Growth Factors: The Fountain of Youth Resides in Us All
Journal of Dental Research, December 1, 1995; 74(12): 1826 - 1832.
[Abstract] [PDF]

Home page
 CROBMHome page
B. Rutherford and M. Fitzgerald
A New Biological Approach To Vital Pulp Therapy
Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(3): 218 - 229.
[Abstract] [Full Text] [PDF]