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Journal of Dental Research
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Change of Salivary IgA Secretion and Caries Development in Irradiated Rats

T. Takei

Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan

W. Aono

Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan

S. Nagashima

Department of Pedodontics

T. Yoshida

Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan

T. Hashida

Oral and Maxillofacial Radiology, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan

S. Sobue

Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan

T. Ooshima

Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan

Xerostomia is a serious side-effect of radiotherapy for head and neck cancer and often enhances caries activity. However, the relationship between caries induction and the IgA level in saliva in rats subjected to irradiation of the salivary glands is unclear. The effect of salivary gland irradiation on salivary function was examined in specific pathogen-free Sprague-Dawley rats infected with or without Streptococcus mutans MT8148R (serotype c). The flow rate of saliva and the protein concentration in saliva were significantly reduced in irradiated rats, regardless of infection of S. mutans. The caries activity was enhanced in these rats, and an irradiation level of 50 Gy significantly increased the caries score. However, longitudinal study indicated that the salivary concentration of IgA reactive with S. mutans whole cells maintained similar or significantly higher levels in irradiated rats, when compared with those of nonirradiated rats. In addition, there was no negative correlation between the caries score and the salivary concentration of IgA reactive with S. mutans. These findings suggest that the secreted IgA against S. mutans may not play a significant role in the caries induction of hyposalivated rats.

Key Words: Dental Caries • Immunoglobulins • Rats • Saliva • Xerostomia.

Journal of Dental Research, Vol. 73, No. 9, 1503-1508 (1994)
DOI: 10.1177/00220345940730090401
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