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Journal of Dental Research
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Incorporation of Bacterial Inhibitor into Resin Composite

S. Imazato

Department of Operative Dentistry, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565, Japan, Department of Oral Biology, The Dental School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4BW, United Kingdom

M. Torii

Department of Operative Dentistry, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565, Japan

Y. Tsuchitani

Department of Operative Dentistry, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565, Japan

J.F. McCabe

Dental Materials Science Unit, The Dental School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4BW, United Kingdom

R.R.B. Russell

Department of Oral Biology, The Dental School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4BW, United Kingdom

Attempts to produce resin composite with antibacterial properties by incorporation of an antibacterial agent such as chlorhexidine have been reported, but problems can arise due to release of the inhibitory agent from the composite. Such problems may include toxic effects, influence on mechanical properties, and loss of effectiveness. A new monomer, methacryloyloxydodecylpyridinium bromide (MDPB), was synthesized by combining an antibacterial agent and methacryloyl group. The monomer was incorporated into resin composite to develop a non-releasing antibacterial composite. The ability of composite incorporating MDPB to inhibit growth and plaque accumulation by Streptococcus mutans in vitro was assayed, elution of antibacterial components from the material was investigated, and the influence of incorporation of MDPB on the mechanical properties of composite was studied. Uncured MDPB revealed antibacterial activity against S. mutans and six other species of oral streptococci, with the minimum inhibitory concentration for S. mutans being comparable with that of triclosan. After composite incorporating MDPB was cured, no elution of the antibacterial components was observed from the material, even after 90 days' immersion in water or other solvents. Growth of S. mutans on agar under specimens of MDPBcontaining composite was inhibited compared with controls. In a bacterial accumulation study, S. mutans accumulated to a lesser degree on the surface of composite incorporating MDPB (p < 0.05) than on control. Incorporation of MDPB had no significant influence on the mechanical properties of the composite.

Key Words: Antimicrobials • Composites • Dental Materials • Resins.

Journal of Dental Research, Vol. 73, No. 8, 1437-1443 (1994)
DOI: 10.1177/00220345940730080701
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