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Presence of Treponema denticola and Porphyromonas gingivalis in Children Correlated with Periodontal Disease of Their Parents

Dallas VA Medical Center, Department of Public Health Sciences, Baylor College of Dentistry, 3302 Gaston Ave., Dallas, Texas 75246

WA Bretz

Department of Cariology and General Dentistry, The University of Michigan School of Dentistry, 1011 North University, Ann Arbor, Michigan 48109-1078

WJ Loesche

Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1011 North University, Ann Arbor, Michigan 48109-1078

Considerable evidence exists suggesting that periodontal disease is due to the overgrowth of a finite number of specific bacteria such as Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Treponema denticola, Bacteroides forsythus, and Prevotella intermedia, among others. Three of these organisms-P. gingivalis, T. denticola, and B. forsythus—can be easily detected in plaque samples by the hydrolysis of the synthetic trypsin substrate benzoyl-DL-arginine-naphthylamide (BANA). The aim of the present study was to determine if a relationship could be found between the presence of either these organisms or periodontitis in the parent and the presence of BANA-positive species in the child. Thirty-four mothers or fathers and 34 children were examined for plaque scores, papillary bleeding scores, and the presence of P. gingivalis and T. denticola in four subgingival or marginal gingival plaque samples as assayed by the BANA test or specific polyclonal antibodies using an ELISA. Children whose parents were colonized by BANA-positive bacteria were 9.8 times more likely to be colonized by these BANA-positive species. Children whose parents had clinical evidence of periodontitis were 12 times more likely to be colonized by these BANA-positive species. These data are compatible with the hypothesis that children may acquire the BANA-positive species from their parents, especially if the parent has periodontitis.

Key Words: Children • Diagnostic Tests • Periodontal Diseases • Porphyromonas gingivalis • Treponema denticola Received July 28,1993; Accepted April 7,1994

Journal of Dental Research, Vol. 73, No. 10, 1636-1640 (1994)
DOI: 10.1177/00220345940730100801


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