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Pulsating Electromagnetic Field Stimulates mRNA Expression of Bone Morphogenetic Protein-2 and -4

M. Nagai

Department of Biochemistry, Iwate Medical University School of Dentistry, Morioka, Iwate 020, Japan

M. Ota

Department of Biochemistry, Iwate Medical University School of Dentistry, Morioka, Iwate 020, Japan

The effects of a pulsating electromagnetic field on mRNA expression of bone morphogenetic protein-2 and -4 in chick embryonic calvaria were examined. From the onset of embryogenesis (Day 0), chick embryos were incubated in a continuously generated pulsating electromagnetic field with a peak of 3.5 milli-Tesla (mean: 2 milli-Tesla) and vibration at 15 Hz. Control chicks were incubated in a normal magnetic field. Northern-blot analysis showed that the mRNAs of bone morphogenetic protein-2 and -4 were expressed in the calvaria. Quantitative analysis of the mRNA expressions was done by means of slot-blot hybridization. The magnetic field enhanced the expressions of both mRNAs. The enhancements were more pronounced in younger chick embryos (Day 15 > Day 17), and no significant change was observed in the 19-day-old embryos. These results indicate that osteo-inductive effects of the magnetic field were mediated at least in part by bone morphogenetic protein-2 and -4.

Key Words: Bone and Bones • Extracellular Matrix Proteins • Bone Morphogenetic Protein • Electromagnetic Field.

Journal of Dental Research, Vol. 73, No. 10, 1601-1605 (1994)
DOI: 10.1177/00220345940730100401
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