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Journal of Dental Research
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Reduction of Proteolytic Degradation by Chlorhexidine

D. Grenier

Groupe de Recherche en Ecologie Buccale, Faculté de Médecine Dentaire, Université Laval, Ste-Foy, Quebec, Canada G1K 7P4

The present investigation was designed to evaluate the effect of the antimicrobial agent chlorhexidine on proteolytic degradation. Chlorhexidine, at a final concentration of 0.01%, significantly (p = 0.05) affected the degradation of the general chromogenic substrate azocoll by both commercial proteases and cell-bound bacterial proteases. Reduction of proteolytic degradation was observed following pre-treatment of either azocoll or bacterial cells with chlorhexidine. Chlorhexidine was also found to prevent degradation oftype I collagen by Porphyromonas gingivalis cells. The mechanism of inhibition of proteolytic degradation appears to be related to an electrostatic chlorhexidine-protein interaction.

Journal of Dental Research, Vol. 72, No. 3, 630-633 (1993)
DOI: 10.1177/00220345930720031301
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