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Initial Dissolution Rate Studies on Dental Enamel after CO2 Laser IrradiationDepartment of Pharmaceutics, University of Utah, Salt Lake City, Utah 84112
Department of Pharmaceutics, University of Utah, Salt Lake City, Utah 84112
Kobe Women's College of Pharmacy, Kobe, Japan
Department of Pharmaceutics, University of Utah, Salt Lake City, Utah 84112
Baxter Healthcare Corporation, Round Lake, Illinois
Department of Dental Education, University of Utah The influence of CO 2 laser irradiation on the dissolution behavior of human dental enamel has been investigated. Human enamel was irradiated by a continuous-wave CO 2 laser at 10.6 µm and initial dissolution rates (IDRs) were measured in 0.1 mol/L acetate buffer, pH = 4.5, both with and without calcium and/or phosphate common ion, by means of a rotating disk assembly. The effects of (1-hydroxyethylidene) bisphosphonic acid (EHDP), fluoride (F), and dodecylamine HCI (DAC) at various levels upon the IDR were also determined. All of the findings were consistent with the hypothesis that CO2 laser irradiation converts dental enamel to hydroxyapatite (HAP) possessing site #2 character (Yamamoto et al., 1986). The dissolution driving force function, KHAP = aca10apO46aOH2, was found to have a value of 10-129.9 after being lased, as compared with 10-121.4 before being lased. The IDR values for EHDP (3 mmol/L) and DAC (3 mmol/L) were essentially zero as expected for site #2 HAP. For solution F, the deduced dissolution driving force function, K FAP = aca10aPO46aF2 was 10-128.6 after being lased as compared with 10-116.3 before being lased. These results all support the hypotheses (1) that laser irradiation may convert the surface of human dental enamel to an apatite of significantly lower effective solubility (i.e., site #2 HAP) than that of unlased enamel; and (2) that there is significant synergism between laser treatment and these chemical dissolution rate inhibitors (again consistent with site #2 HAP). Simple model calculations indicate that, in both the presence and absence of fluoride, these laser-induced changes in the driving force for dissolution should dramatically lessen the susceptibility of enamel to the types of acid challenge that might be encountered in the mouth
Journal of Dental Research, Vol. 71, No. 7,
1389-1398 (1992) This article has been cited by other articles:
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