Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Marks, R.G.
Right arrow Articles by Cancro, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marks, R.G.
Right arrow Articles by Cancro, L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

A Fluoride Dose-response Evaluation in an Anticaries Clinical Trial

R.G. Marks

J-212 JHMHC, Division of Biostatistics, Department of Statistics, University of Florida, Gainesville, FL 32610

R. D'Agostino

Department of Mathematics, Boston University, Boston, MA 02215

J.E. Moorhead

J-212 JHMHC, Division of Biostatistics, Department of Statistics, University of Florida, Gainesville, FL 32610

A.J. Conti

J-404 JHMHC, Department of Community Dentistry, College of Dentistry, University of Florida, Gainesville, FL 32610

L. Cancro

Chesebrough-Pond's Inc., Trumbull, CT 06611

This study evaluated the dose-response relationship between four increasing levels of fluoride from 1000 to 2500 ppm F as sodium monofluorophosphate (MFP) and three-year dental caries increments, as measured by DMFS, DMFT, and DFS-A on 4424 schoolchildren. The results indicated consistent linear decreases in all three dental indices as the dose level increased to 2500 ppm F MFP, with slopes (average reductions) of 0.32 in DMFS for an increase of 1000 ppm F, 0.13 in DMFT, and 0.17 in DFS-A when all children were evaluated, p < 0.03 for each index. For children 11 years and older at baseline, the slopes quadrupled, p < 0.01 for each index. Age and baseline DMFS were shown to be the most important covariates to control for in the statistical models. No differences in adverse reactions, or other safety problems, were observed at the different dose levels.

Journal of Dental Research, Vol. 71, No. 6, 1286-1291 (1992)
DOI: 10.1177/00220345920710060401
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JDRHome page
A.R. Biesbrock, R.K. Chesters, R.P. Ellwood, and S.R. Smith
The Challenges of Validating Diagnostic Methods Relative to a Conventional Two-year Caries Clinical Trial
Journal of Dental Research, July 1, 2004; 83(suppl_1): C53 - C55.
[Abstract] [Full Text] [PDF]