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Journal of Dental Research
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Immunohistochemical Evidence for the Occurrence of Endothelin in the Vascular Endothelium of Normal and Inflamed Human Dental Pulp

A. Casasco

Institute of Histology and Embryology, University of Pavia, via Forlanini 10, 27100 Pavia, Italy

M. Casasco

Institute of Histology and Embryology, University of Pavia, via Forlanini 10, 27100 Pavia, Italy

M. Ciuffreda

Dental Clinic, Department of Endodontics, "S. Matteo" Hospital, University of Pavia, 27100 Pavia, Italy

D.R. Springall

Histochemistry Unit, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, England

A. Calligaro

Institute of Histology and Embryology, University of Pavia, via Forlanini 10, 27100 Pavia, Italy

S. Bianchi

Dental Clinic, Department of Endodontics, "S. Matteo" Hospital, University of Pavia, 27100 Pavia, Italy

J.M. Polak

Histochemistry Unit, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, England

The occurrence and distribution ofthe regulatory peptide endothelin in normal and inflamed human dental pulp was studied by immunocytochemistry. Endothelial cells in both normal and inflamed pulp displayed endothelin-like immunoreactivity. Neither pulp cells nor dental nerves were immunoreactive. No significant change in the distribution of endothelin immunoreactivity could be detected in the samples of inflamed pulp tissue, the immunoreactive material being detectable only within the endothelium. However, the intensity of the immunostaining was less intense in the samples of inflamed pulp. It is reasonable to presume that endothelin, produced and released locally by endothelial cells, may participate via a paracrine mechanism in the regulation of blood pressure and flow in normal and pathological human dental tissues.

Journal of Dental Research, Vol. 71, No. 3, 475-477 (1992)
DOI: 10.1177/00220345920710031001
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