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In vivo Fluoride Concentrations Measured for Two Hours After a NaF or a Novel Two-solution Rinse

American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Polymers Division, Gaithersburg, Maryland 20899

Y. Mao

American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Polymers Division, Gaithersburg, Maryland 20899

C.M. Carey

American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Polymers Division, Gaithersburg, Maryland 20899

L.C. Chow

American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Polymers Division, Gaithersburg, Maryland 20899

S. Takagi

American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Polymers Division, Gaithersburg, Maryland 20899

The concentrations of fluoride in various samples from the oral environment were measured at timed intervals after a novel rinse or a NaF rinse, both containing a total of 12 mmol/L (228 ppm) fluoride. The novel rinse consisted of two solutions mixed just before application: Part A contained calcium chloride and sodium acetate; part B contained a hydrolyzable source of fluoride (sodium hexafluorosilicate) and sodium phosphate. Samples were obtained as follows: Single-site plaque-fluid samples were obtained by centrifugation of first-molar plaque; pooled whole-plaque samples were collected from second molars; centrifuged, pooled whole-saliva was collected by vacuum. All samples were analyzed by micro-analytical methods. Results showed that, compared with NaF, the two-solution rinse produced significantly higher salivary fluoride concentrations, plaque-fluid fluoride concentrations, and acid-extractable fluoride in the whole plaque by factors of about 4, 2, and 6, respectively, at 120 min. The results of this study suggest that the new rinse may provide a greater cariostatic effect at the same fluoride dosage than does a NaF rinse.

Journal of Dental Research, Vol. 71, No. 3, 448-452 (1992)
DOI: 10.1177/00220345920710030501


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