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Effect of a Two-solution Fluoride Mouthrinse on Remineralization of Enamel Lesions in vitro

American Dental Association Health Foundation, Paffenbarger Research Center, Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899

S. Takagi

American Dental Association Health Foundation, Paffenbarger Research Center, Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899

S. Shih

American Dental Association Health Foundation, Paffenbarger Research Center, Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899

A previous study showed that a two-solution fluoride (F) rinse deposited significantly more loosely-bound F on the tooth surface than did a sodium fluoride (NaF) rinse with the same F concentration (12 mmol/L). In the present study, this experimental rinse was evaluated for its ability to cause remineralization of enamel lesions in an in vitro pH-cycling model. Caries-like lesions were formed in the enamel of extracted human molars by means of a pH 4 demineralizing solution. Fifty-one ~120-µm-thick sections containing lesions were randomly divided into (1) control, (2) NaF rinse, and (3) two-solution F rinse groups. With the cut surfaces protected, the control samples were immersed in a pH 7 remineralizing solution for 12 days, and twice daily the sections were also exposed to a pH 4 demineralizing solution for 30 min. Samples in the NaF group received an additional one-minute rinse with a NaF (12 mmol/L) solution twice daily. Samples in the two-solution rinse group received the rinse treatment with a 12 mmol/L F solution prepared by combination of a Na₂SiF ₆ and phosphate-containing solution with a calcium solution just before use. The mineral contents of the lesions were assessed by quantitative microradiography. The results showed that (1) no significant de- or remineralization was detected in the controls; (2) a 46% decrease in mineral loss (AZ) ofthe lesion was produced by the NaF rinses; and (3) a 94% decrease in AZ and a 20-µm-thick, mineral-dense surface-coating were produced by the two-solution F rinse treatment.

Journal of Dental Research, Vol. 71, No. 3, 443-447 (1992)
DOI: 10.1177/00220345920710030401


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