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Journal of Dental Research
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*PROPRANOLOL HYDROCHLORIDE
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What's this?

Effect of a Beta-adrenergic Blocking Agent on Dental Anxiety

H.H. Liu

Faculty of Dentistry, National University of Singapore, Singapore 0511

P. Milgrom

Dental Fears Research Clinic, Department of Dental Public Health Sciences, University of Washington, Seattle, Washington 98195

L. Fiset

Dental Fears Research Clinic, Department of Dental Public Health Sciences, University of Washington, Seattle, Washington 98195

The effect of propranolol was studied on 23 dental phobics in a double-blind, placebo-controlled clinical trial involving actual dental treatment. The subjects were selected because they showed high physiological reactivity in the dental situation. Twelve subjects received the test drug and 11 subjects received the placebo at individualized doses of either 80 or 120 mg. A significant difference in self-reported anxiety at the injection phase of treatment and less overall pain intensity and aversiveness were observed for the propranolol as compared with the placebo group. No differences were detected for behavior ratings. Beta-adrenergic blocking agents may have utility for reducing anxiety in individuals fearful of dental treatment.

Journal of Dental Research, Vol. 70, No. 9, 1306-1308 (1991)
DOI: 10.1177/00220345910700091401
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