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Journal of Dental Research
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Immunocytochemical Evidence for the Site of O-methylation in Rat Dental Pulp

K. Inoue

Department of Oral Anatomy, Okayama University, Dental School, Okayama 700, Japan

T. Nishino

Department of Oral Anatomy, Okayama University, Dental School, Okayama 700, Japan

C.R. Creveling

Laboratory of Bio-organic Chemistry, NIDDK, NIH, Bethesda, Maryland 20892

Immunocytochemical observations by light and electron microscopy of catechol-O-methyltransferase (COMT) were conducted in dental pulp by use of a specific antibody to soluble rat-liver COMT and the peroxidase-antiperoxidase technique. Immunoreactive deposits were found in macrophages. The pattern of localization suggests that COMT may function in extraneuronal inactivation of catecholamines in dental pulp.

Journal of Dental Research, Vol. 70, No. 6, 966-969 (1991)
DOI: 10.1177/00220345910700061101
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