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Protection of Rats Against Dental Caries by Passive Immunization With Hen-egg-yolk Antibody (IgY)

Department of Clinical Pathology, Nihon University School of Dentistry at Matsudo, 870-1, Sakaecho-nishi 2, Matsudo, Chiba 271, Japan

Y. Nishihara

Department of Clinical Pathology, Nihon University School of Dentistry at Matsudo, 870-1, Sakaecho-nishi 2, Matsudo, Chiba 271, Japan

M. Makimura

Department of Clinical Pathology, Nihon University School of Dentistry at Matsudo, 870-1, Sakaecho-nishi 2, Matsudo, Chiba 271, Japan

H. Hatta

Central Research Laboratories, Taiyo Kagaku Co., Ltd., Yokkaichi, 510, Japan

M. Kim

Central Research Laboratories, Taiyo Kagaku Co., Ltd., Yokkaichi, 510, Japan

T. Yamamoto

Central Research Laboratories, Taiyo Kagaku Co., Ltd., Yokkaichi, 510, Japan

M. Hirasawa

Department of Microbiology, Nihon University School of Dentistry at Matsudo, 870-1, Sakaecho-nishi 2, Matsudo, Chiba 271, Japan

Hen-egg-yolk antibody (IgY) was prepared against Streptococcus mutans MT8148 serotype c that was cultivated in medium containing sucrose, and it was used in passive caries-immunity studies. Specific pathogen-free rats infected with S. mutans MT8148 (c) and fed with a cariogenic diet containing more than 2% immune yolk powder developed significantly lower caries scores than did the ones infected with the same strain and fed with a diet containing only control yolk powder obtained from non-immunized hens. Similar results were obtained in an experiment with rats infected with S. mutans JC-2 (c) strain. Rats provided a diet supplemented with 0.5% immune water-soluble protein fraction containing S. mutans-specific IgY and challenged with S. mutans MT8148 exhibited significantly fewer caries lesions, compared with control rats on the normal diet.

Journal of Dental Research, Vol. 70, No. 3, 162-166 (1991)
DOI: 10.1177/00220345910700030101


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