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Journal of Dental Research
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Power and Sample Size Calculations for Clinical Trials of Myofascial Pain of Jaw Muscles

T.T.T. Dao

Faculté de medecine dentaire et Centre de recherche en sciences neurologiques, Université de Montreal, C.P. 6128, Succ. A, Montreal, PQ, Canada H3C 3J7

G.J. Lavigne

Faculté de medecine dentaire et Centre de recherche en sciences neurologiques, Université de Montreal, C.P. 6128, Succ. A, Montreal, PQ, Canada H3C 3J7

J.S. Feine

Faculté de medecine dentaire et Centre de recherche en sciences neurologiques, Université de Montreal, C.P. 6128, Succ. A, Montreal, PQ, Canada H3C 3J7

R. Tanguay

Faculté de medecine dentaire et Centre de recherche en sciences neurologiques, Université de Montreal, C.P. 6128, Succ. A, Montreal, PQ, Canada H3C 3J7

J.P. Lund

Faculté de medecine dentaire et Centre de recherche en sciences neurologiques, Université de Montreal, C.P. 6128, Succ. A, Montreal, PQ, Canada H3C 3J7

When a clinical trial is planned, the approximate number of subjects needed for significant differences between/among groups to be detected must be estimated. Sample-size calculations provide the investigator with this information.

This paper discusses the choice of outcome measures and describes the steps used to estimate the numbers of subjects necessary for a study that compares treatments for patients with chronic myofascial pain of jaw muscles. Within- and between-subject variances were estimated for the chosen variables, the subjects' pain ratings on visual analogue scales. Sample sizes were then calculated for theoretical differences between groups by pre-treatment means and overall standard deviations (Cohen, 1977).

The results of this analysis can be used by other researchers when planning studies involving these types of patients.

Journal of Dental Research, Vol. 70, No. 2, 118-122 (1991)
DOI: 10.1177/00220345910700020401
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