Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Van Loveren, C.
Right arrow Articles by Eisenberg, A.D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Loveren, C.
Right arrow Articles by Eisenberg, A.D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

In vitro Demineralization of Enamel by F-sensitive and F-resistant Mutans Streptococci in the Presence of 0, 0.05, or 0.5 mmol/L NaF

C. Van Loveren

Department of Cariology and Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), Louwesweg 1, 1066 EA Amsterdam, The Netherlands

L.M. Spitz

Department of Oral Biology Eastman Dental Center, 625 Elmwood Avenue Rochester, New York 14620

J.F. Buijs

Department of Cariology and Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), Louwesweg 1, 1066 EA Amsterdam, The Netherlands

J.M. Ten Cate

Department of Cariology and Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), Louwesweg 1, 1066 EA Amsterdam, The Netherlands

A.D. Eisenberg

Department of Oral Biology Eastman Dental Center, 625 Elmwood Avenue Rochester, New York 14620

Lactate production and accompanying enamel demineralization by fluoride-sensitive and fluoride-resistant mutans streptococci were studied in an in vitro demineralization model in the presence of 0, 0.05, or 0.5 mmol/L NaF. The fluoride-resistant strains were derived from laboratory strains or were recently isolated strains from xerostomic patients on high-dose fluoride therapy. The demineralization model was composed of a cell suspension in a glucose-agarose gel overlying a bovine enamel block. Lactate and calcium content of the agarose were determined after 22-hour incubations at 37°C.

Fluoride-resistant variants of Streptococcus sobrinus 6715-15 produced less lactate and caused less demineralization than did the parent strain even in the presence of fluoride. On the other hand, fluoride-resistant variants of Streptococcus mutans C180-2 and of S. mutans GS-5 produced more acid and caused greater demineralization than did their respective parent strains, both in the absence and presence of fluoride. Two recently isolated fluoride-resistant S. mutans strains produced more lactate and demineralized enamel more than did two recently isolated S. mutans strains from normal human subjects, both in the presence of 0 and 0.05 mmol/L NaF.

It is concluded that adaptation to fluoride resistance does not invariably reduce the cariogenicity of mutans streptococci nor the effectiveness of fluoride in preventing demineralization.

Journal of Dental Research, Vol. 70, No. 12, 1491-1496 (1991)
DOI: 10.1177/00220345910700120401
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
C. van Loveren, J. F. Buijs, and J. M. ten Cate
The effect of triclosan toothpaste on enamel demineralization in a bacterial demineralization model
J. Antimicrob. Chemother., February 1, 2000; 45(2): 153 - 158.
[Abstract] [Full Text] [PDF]

Home page
 ADRHome page
D.J. White
The Application of in Vitro Models to Research on Demineralization and Remineralization of the Teeth
Advances in Dental Research, November 1, 1995; 9(3): 175 - 193.
[Abstract] [PDF]

Home page
 ADRHome page
G.H. Bowden
The Role of Microbiology in Models of Dental Caries: Reaction Paper
Advances in Dental Research, November 1, 1995; 9(3): 255 - 269.
[Abstract] [PDF]

Home page
 JDRHome page
N. Guha-Chowdhury, Y. Iwami, T. Yamada, and E.I.F. Pearce
The Effect of Fluorhydroxyapatite-derived Fluoride on Acid Production by Streptococci
Journal of Dental Research, September 1, 1995; 74(9): 1618 - 1624.
[Abstract] [PDF]

Home page
 JDRHome page
C. Van Loveren, J.F. Buijs, and J.M. Ten Cate
Protective Effect of Topically Applied Fluoride in Relation to Fluoride Sensitivity of Mutans Streptococci
Journal of Dental Research, August 1, 1993; 72(8): 1184 - 1190.
[Abstract] [PDF]