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Age-related Changes in Mucins from Human Whole Saliva
P.C. Denny
Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641
P.A. Denny
Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641
D.K. Klauser
Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641
S.H. Hong
Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641
M. Navazesh
Department of Dental Medicine and Public Health, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641
L.A. Tabak
Departments of Dental Research and Biochemistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14646
The predominant mucins in human whole saliva, MG1 and MG2, serve to protect and to lubricate the oral cavity. In this study, both unstimulated and stimulated whole salivas were collected from two groups of subjects: young (18-35 years of age) and aged (65-83 years of age). The subjects were in apparent good health. Saliva samples from each subject were analyzed by SDS-PAGE. The gels were stained with Stains-all, and both MG1 and MG2 were quantitated by video-image densitometry. The protocol gave reproducible values for each mucin. The stimulated and unstimulated salivas from aged subjects showed significant reductions in concentrations of both MG1 and MG2, as quantitated in mucin dye-binding units. Possible associations of these reductions with the aging process are discussed.
Journal of Dental Research, Vol. 70, No. 10,
1320-1327 (1991)
DOI: 10.1177/00220345910700100201
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