This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Denny, P.C. Articles by Tabak, L.A. Search for Related Content PubMed Articles by Denny, P.C. Articles by Tabak, L.A. Social Bookmarking                   What's this?

Age-related Changes in Mucins from Human Whole Saliva

Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641

P.A. Denny

Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641

D.K. Klauser

Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641

S.H. Hong

Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641

M. Navazesh

Department of Dental Medicine and Public Health, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641

L.A. Tabak

Departments of Dental Research and Biochemistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14646

The predominant mucins in human whole saliva, MG1 and MG2, serve to protect and to lubricate the oral cavity. In this study, both unstimulated and stimulated whole salivas were collected from two groups of subjects: young (18-35 years of age) and aged (65-83 years of age). The subjects were in apparent good health. Saliva samples from each subject were analyzed by SDS-PAGE. The gels were stained with Stains-all, and both MG1 and MG2 were quantitated by video-image densitometry. The protocol gave reproducible values for each mucin. The stimulated and unstimulated salivas from aged subjects showed significant reductions in concentrations of both MG1 and MG2, as quantitated in mucin dye-binding units. Possible associations of these reductions with the aging process are discussed.

Journal of Dental Research, Vol. 70, No. 10, 1320-1327 (1991)
DOI: 10.1177/00220345910700100201


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M.-A. Peyron, O. Blanc, J. P. Lund, and A. Woda Influence of Age on Adaptability of Human Mastication J Neurophysiol, August 1, 2004; 92(2): 773 - 779. [Abstract] [Full Text] [PDF]

				K. A. Thomsson, A. Prakobphol, H. Leffler, M. S. Reddy, M. J. Levine, S. J. Fisher, and G. C. Hansson The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse Glycobiology, January 1, 2002; 12(1): 1 - 14. [Abstract] [Full Text] [PDF]

				J.D. Rudney Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health? Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(4): 343 - 367. [Abstract] [Full Text] [PDF]

				A. Aguirre, L.A. Testa-Weintraub, J.A. Banderas, G.G. Haraszthy, M.S. Reddy, and M.J. Levine Sialochemistry: A Diagnostic Tool? Critical Reviews in Oral Biology & Medicine, January 1, 1993; 4(3): 343 - 350. [Abstract] [Full Text] [PDF]

				M. Navazesh, R.A. Mulligan, V. Kipnis, P.A. Denny, and P.C. Denny Comparison of Whole Saliva Flow Rates and Mucin Concentrations in Healthy Caucasian Young and Aged Adults Journal of Dental Research, June 1, 1992; 71(6): 1275 - 1278. [Abstract] [PDF]