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Journal of Dental Research
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The Possible Role of Oral Epithelial Cells in Tissue-type Plasminogen Activator-related Fibrinolysis in Human Saliva

S. Sindet-Pedersen

Department of Oral and Maxillofacial Surgery, Århus University Hospital, Nørrebrogade, DK-8000 Århus C, Denmark

J. Gram

Section of Coagulation and Fibrinolysis, Department of Clinical Chemistry, Ribe County Hospital, Østergade, DK-6700 Esbjerg, Denmark

J. Jespersen

Section of Coagulation and Fibrinolysis, Department of Clinical Chemistry, Ribe County Hospital, Østergade, DK-6700 Esbjerg, Denmark

We studied the fibrinolytic activities of the following subfractions of unstimulated human whole saliva on plasminogen-rich fibrin plates: (1) submandibular saliva, (2) parotid saliva, and (3) smears of buccal epithelial cells from ten healthy males. A cell-bound plasminogen activator could be demonstrated in the sediments of all three subfractions of whole saliva. The incorporation of antibodies (goat IgG) against human two-chain tissue-type plasminogen activator (t-PA) could quench the assessed fibrinolytic activities, whereas additional experiments suggested the absence of urokinase-like and F XII-dependent activators of fibrinolysis. The determinations in growth medium from buccal-epithelial cell culture of t-PA antigen by means of enzyme-linked immunosorbent assay showed the presence of t-PA.

These clinical and experimental findings suggest that buccal-epithelial cells produce t-PA, while the activity of t-PA in parotid and submandibular saliva is very low.

Journal of Dental Research, Vol. 69, No. 6, 1283-1286 (1990)
DOI: 10.1177/00220345900690061201
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