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Caries Incidence in Intact Rats Infected with Streptococcus sobrinus via Transmission from Desalivated Cagemates

University of Rochester, Rochester Cariology Center, Department of Dental Research, 601 Elmwood Avenue, Rochester, New York 14642

W.H. Bowen

University of Rochester, Rochester Cariology Center, Department of Dental Research, 601 Elmwood Avenue, Rochester, New York 14642

S.K. Pearson

University of Rochester, Rochester Cariology Center, Department of Dental Research, 601 Elmwood Avenue, Rochester, New York 14642

J.L. Falany

University of Rochester, Rochester Cariology Center, Department of Dental Research, 601 Elmwood Avenue, Rochester, New York 14642

The purpose of this study was to determine the influence of caging desalivated S. sobrinus-infected rats on the caries incidence in intact, previously uninfected cagemates. Weanlings were divided as follows: Stage I: Twenty desalivated animals paired with 20 intact animals (Group I); 20 intact animals paired with 20 intact animals (Group II). Animals were infected with S. sobrinus and fed diet 2000 and 10% sucrose water. After five weeks, ten paired animals from each group were killed. Desalivated animals had statistically higher (p<0.05) caries scores than did other animals. Stage II: The remaining Stage I infected animals from Groups I and II were paired with 40 new uninfected animals 15 days of age and fed cariogenic diets. After five weeks, new intact animals paired with Stage I desalivated animals had significantly higher smooth-surface enamel caries scores (38.0; SE 7.84) than new intact animals paired with Stage I intact animals (11.15 ; SE 3.69). Moreover, new intact animals caged for only five weeks with Stage I desalivated animals developed smooth-surface caries (38.0; SE 7.84) to a degree comparable with that in all Stage I intact animals in the experiment for ten weeks (36.6, SE 9.5 ; and 30.05, SE 4.1). The data suggest that desalivation may select a readily transmissible strain of S. sobrinus, which demonstrates enhanced virulence.

Journal of Dental Research, Vol. 69, No. 5, 1154-1159 (1990)
DOI: 10.1177/00220345900690050701


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