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Bacterial Adhesion to Oral Tissues: A Model for Infectious Diseases
R.J. Gibbons
Forsyth Dental Center and Harvard School of Dental Medicine, 140 Fenway, Boston, Massachusetts 02115
The majority of bacteria which colonize humans display sharp host and tissue tropisms; consequently, relatively little is known about how they initiate colonization on mucosal surfaces. The mouth has a variety of features which have enabled it to serve as a useful model for the discovery of basic principles of host-parasite interactions occurring in mucosal environments. Early studies demonstrated that indigenous bacteria attach to surfaces of the mouth in a highly selective manner; attachment was often observed to correlate with colonization. These studies led to the recognition that bacterial attachment is an essential step for colonization in environments which contain surfaces exposed to a fluid flow. Bacterial adhesion has subsequently grown into a major area of infectious disease research. Many bacteria have been found to possess proteinaceous components, called "adhesins", on their surfaces which bind in a stereochemically specific manner to complementary molecules, or "receptors", on the tissue surface. Adhesins are often lectins which bind to saccharide receptors, but some adhesins are thought to bind to proteinaceous receptors. Studies of components of human saliva, which adsorb to hydroxyapatite (HA) surfaces similar to those of teeth, and promote the attachment of prominent plaque bacteria, have revealed that the acidic proline-rich proteins (PRPs) promote the attachment of several important bacteria. These include strains of Actinomyces viscosus, Bacteroides gingival is, some strains of Streptococcus mutans, and others. The salivary PRP's are a unique family of molecules. However, segments of PRPs are structurally related to collagen. This may be significant, since B. gingivalis and certain cariogenic streptococci bind to collagenous substrata, and such interactions may facilitate their invasion into gingival tissues, or into dentin or cementum, respectively. Another unexpected observation was that although A. viscosus and other bacteria bind avidly to PRPs adsorbed onto apatitic surfaces, they do not interact with PRPs in solution. PRP molecules evidently undergo a conformational change when they adsorb to HA, and adhesins of A. viscosus recognize cryptic segments which are only exposed in adsorbed molecules. This provides the bacteria with a mechanism for efficiently attaching to teeth while suspended in saliva. It also offers a molecular explanation for their sharp tropisms for human teeth. It has proven convenient to refer to such hidden receptors for bacterial adhesins as "cryptitopes" (from cryptic, meaning hidden, and topo, meaning place). The generation of cryptitopes due to conformational changes or because of enzymatic modifications appears to be involved in the colonization of several bacteria on mucosal surfaces. In addition, there is evidence which suggests that elevated levels of neuraminidases and proteases associated with poor oral hygiene and gingivitis may also generate cryptitopes which promote colonization of certain Gram-negative bacteria associated with destructive periodontal diseases. These enzymes concurrently destroy receptors required for attachment of relatively benign species such as S. mitis and S. sanguis. Thus, the elevated levels of enzymes previously reported present in crevicular fluid and saliva of individuals with poor oral hygiene appear to have the potential to modulate bacterial colonization.
Journal of Dental Research, Vol. 68, No. 5,
750-760 (1989)
DOI: 10.1177/00220345890680050101
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|
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51(10):
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|
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74(11):
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|
|
|
|
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|
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281(22):
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|
|
|
|
|
|
|
J. A. Aas, B. J. Paster, L. N. Stokes, I. Olsen, and F. E. Dewhirst
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[Abstract]
[Full Text]
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|
|
|
|
|
|
|
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Clin. Vaccine Immunol.,
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12(6):
764 - 769.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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Inactivation of Streptococcus gordonii SspAB Alters Expression of Multiple Adhesin Genes
Infect. Immun.,
June 1, 2005;
73(6):
3351 - 3357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ruhl, S.A. Rayment, G. Schmalz, K.-A. Hiller, and R.F. Troxler
Proteins in Whole Saliva during the First Year of Infancy
Journal of Dental Research,
January 1, 2005;
84(1):
29 - 34.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. A. El-Solh, C. Pietrantoni, A. Bhat, M. Okada, J. Zambon, A. Aquilina, and E. Berbary
Colonization of Dental Plaques: A Reservoir of Respiratory Pathogens for Hospital-Acquired Pneumonia in Institutionalized Elders
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November 1, 2004;
126(5):
1575 - 1582.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Bosch, M. Turkenburg, K. Nazmi, E. C. I. Veerman, E. J. C. de Geus, and A. V. Nieuw Amerongen
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Psychosom Med,
July 1, 2003;
65(4):
604 - 612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Oho, M. Mitoma, and T. Koga
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Infect. Immun.,
September 1, 2002;
70(9):
5279 - 5282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Kleinberg
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March 1, 2002;
13(2):
108 - 125.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.M. Love and H.F. Jenkinson
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Critical Reviews in Oral Biology & Medicine,
March 1, 2002;
13(2):
171 - 183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Nakagawa, A. Amano, M. Kuboniwa, T. Nakamura, S. Kawabata, and S. Hamada
Functional Differences among FimA Variants of Porphyromonas gingivalis and Their Effects on Adhesion to and Invasion of Human Epithelial Cells
Infect. Immun.,
January 1, 2002;
70(1):
277 - 285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Li, M. K. Khah, S. Slavnic, I. Johansson, and N. Stromberg
Different Type 1 Fimbrial Genes and Tropisms of Commensal and Potentially Pathogenic Actinomyces spp. with Different Salivary Acidic Proline-Rich Protein and Statherin Ligand Specificities
Infect. Immun.,
December 1, 2001;
69(12):
7224 - 7233.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. Demuth, D. C. Irvine, J. W. Costerton, G. S. Cook, and R. J. Lamont
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September 1, 2001;
69(9):
5736 - 5741.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Lenander-Lumikari and V. Loimaranta
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Advances in Dental Research,
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14(1):
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[Abstract]
[PDF]
|
|
|
|
|
|
|
S. KATO, K. NAKASHIMA, M. INOUE, J. TOMIOKA, K. NONAKA, T. NISHIHARA, and Y. KOWASHI
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|
|
|
|
|
|
|
K. Gong, L. Mailloux, and M. C. Herzberg
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275(12):
8970 - 8974.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
C. Y. Loo, D. A. Corliss, and N. Ganeshkumar
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J. Bacteriol.,
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182(5):
1374 - 1382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Takahashi and T. Yamada
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10(4):
487 - 503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.K. Yeung
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January 1, 1999;
10(2):
120 - 138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kotiranta, M. Haapasalo, K. Kari, E. Kerosuo, I. Olsen, T. Sorsa, J. H. Meurman, and K. Lounatmaa
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Infect. Immun.,
October 1, 1998;
66(10):
4895 - 4902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Hallberg, C. Holm, U. Ohman, and N. Stromberg
Actinomyces naeslundii Displays Variant fimP and fimA Fimbrial Subunit Genes Corresponding to Different Types of Acidic Proline-Rich Protein and beta -Linked Galactosamine Binding Specificity
Infect. Immun.,
September 1, 1998;
66(9):
4403 - 4410.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Amano, S. Shizukuishi, H. Horie, S. Kimura, I. Morisaki, and S. Hamada
Binding of Porphyromonas gingivalis Fimbriae to Proline-Rich Glycoproteins in Parotid Saliva via a Domain Shared by Major Salivary Components
Infect. Immun.,
May 1, 1998;
66(5):
2072 - 2077.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.A. Burne
Oral Streptococci... Products of Their Environment
Journal of Dental Research,
March 1, 1998;
77(3):
445 - 452.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. H.W. Bowden and I. R. Hamilton
Survival of Oral Bacteria
Critical Reviews in Oral Biology & Medicine,
January 1, 1998;
9(1):
54 - 85.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Carlen, P. Bratt, C. Stenudd, J. Olsson, and N. Stromberg
Agglutinin and Acidic Proline-rich Protein Receptor Patterns May Modulate Bacterial Adherence and Colonization on Tooth Surfaces
Journal of Dental Research,
January 1, 1998;
77(1):
81 - 90.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A.S. Landa, H.C. Van Der Mei, and H.J. Busscher
Detachment of Linking Film Bacteria From Enamel Surfaces by Oral Rinses and Penetration of Sodium Lauryl Sulphate Through an Artificial Oral Biofilm
Advances in Dental Research,
November 1, 1997;
11(4):
528 - 538.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R.P. Ellen, G. Lepine, and P.-M. Nghiem
In Vitro Models That Support Adhesion Specificity in Biofilms of Oral Bacteria
Advances in Dental Research,
April 1, 1997;
11(1):
33 - 42.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G.H.W. Bowden and Y.H. Li
Nutritional Influences on Biofilm Development
Advances in Dental Research,
April 1, 1997;
11(1):
81 - 99.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.O. Cisar, Y. Takahashi, S. Ruhl, J.A. Donkersloot, and A.L. Sandberg
Specific Inhibitors of Bacterial Adhesion: Observations From the Study of Gram-Positive Bacteria that Initiate Biofilm Formation on the Tooth Surface
Advances in Dental Research,
April 1, 1997;
11(1):
168 - 175.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. D. Marsh and D. J. Bradshaw
Physiological Approaches to the Control of Oral Biofilms
Advances in Dental Research,
April 1, 1997;
11(1):
176 - 185.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D.H. Meyer, K.P. Mintz, and P.M. Fives-Taylor
Models of Invasion of Enteric and Periodontal Pathogens Into Epithelial Cells: A Comparative Analysis
Critical Reviews in Oral Biology & Medicine,
January 1, 1997;
8(4):
389 - 409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Denee Thomas
Aspects of Adherence of Oral Spirochetes
Critical Reviews in Oral Biology & Medicine,
January 1, 1996;
7(1):
4 - 11.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.F. Liljemark and C. Bloomquist
Human Oral Microbial Ecology and Dental Caries and Periodontal Diseases
Critical Reviews in Oral Biology & Medicine,
January 1, 1996;
7(2):
180 - 198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Leonhardt, J. Olsson, and G. Dahlen
Bacterial Colonization on Titanium, Hydroxyapatite, and Amalgam Surfaces in vivo
Journal of Dental Research,
September 1, 1995;
74(9):
1607 - 1612.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D.A. Johnson, H. Lopez, and J.M. Navia
Effects of Protein Deficiency and Diet Consistency on the Parotid Gland and Parotid Saliva of Rats
Journal of Dental Research,
August 1, 1995;
74(8):
1444 - 1452.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F.A. Scannapieco, G.I. Torres, and M.J. Levine
Salivary Amylase Promotes Adhesion of Oral Streptococci to Hydroxyapatite
Journal of Dental Research,
July 1, 1995;
74(7):
1360 - 1366.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F. Lagerlof
Caries-Protective Factors in Saliva
Advances in Dental Research,
July 1, 1994;
8(2):
229 - 238.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Aa. Scheie
Mechanisms of Dental Plaque Formation
Advances in Dental Research,
July 1, 1994;
8(2):
246 - 253.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C.W.I. Douglas
Bacterial-Protein Interactions in the Oral Cavity
Advances in Dental Research,
July 1, 1994;
8(2):
254 - 262.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P.D. Marsh
Microbial Ecology of Dental Plaque and its Significance in Health and Disease
Advances in Dental Research,
July 1, 1994;
8(2):
263 - 271.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.M. ten Cate and P.D. Marsh
Procedures for Establishing Efficacy of Antimicrobial Agents for Chemotherapeutic Caries Prevention
Journal of Dental Research,
March 1, 1994;
73(3):
695 - 703.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F. A. Scannapieco
Saliva-Bacterium Interactions in Oral Microbial Ecology
Critical Reviews in Oral Biology & Medicine,
January 1, 1994;
5(3):
203 - 248.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Steinberg, L.K. Kopec, and W.H. Bowen
Adhesion of Actinomyces Isolates to Experimental Pellicles
Journal of Dental Research,
June 1, 1993;
72(6):
1015 - 1020.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. K. Kuramitsu
Virulence Factors of Mutans Streptococci: Role of Molecular Genetics
Critical Reviews in Oral Biology & Medicine,
January 1, 1993;
4(2):
159 - 176.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.D. Bradway and M.J. Levine
Do Proline-rich Proteins Modulate a Transglutaminase Catalyzed Mechanism of Candidal Adhesion?
Critical Reviews in Oral Biology & Medicine,
January 1, 1993;
4(3):
293 - 299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. W. Stinson and M. J. Levine
Modulation of Intergeneric Adhesion of Oral Bacteria by Human Saliva
Critical Reviews in Oral Biology & Medicine,
January 1, 1993;
4(3):
309 - 314.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P.D. Marsh
Microbiological Aspects of the Chemical Control of Plaque and Gingivitis
Journal of Dental Research,
July 1, 1992;
71(7):
1431 - 1438.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. J. Smith and M. A. Taubman
Ontogeny of Immunity to Oral Microbiota in Humans
Critical Reviews in Oral Biology & Medicine,
January 1, 1992;
3(1):
109 - 133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Li, R.P. Ellen, C.I. Hoover, and J.R. Felton
Association of Proteases of Porphyromonas (Bacteroides) gingivalis with its Adhesion to Actinomyces viscosus
Journal of Dental Research,
February 1, 1991;
70(2):
82 - 86.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. C. Holt and T. E. Bramanti
Factors in Virulence Expression and Their Role in Periodontal Disease Pathogenesis
Critical Reviews in Oral Biology & Medicine,
January 1, 1991;
2(2):
177 - 281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Boackle
The Interaction of Salivary Secretions with the Human Complement System -- A Model for the Study of Host Defense Systems on Inflamed Mucosal Surfaces
Critical Reviews in Oral Biology & Medicine,
January 1, 1991;
2(3):
355 - 367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.W.I. Douglas
Characterization of the {alpha}-amylase Receptor of Streptococcus gordonii NCTC 7868
Journal of Dental Research,
November 1, 1990;
69(11):
1746 - 1752.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Olsson, A. Carlen, and K. Holmberg
Inhibition of Streptococcus mutans Adherence by Means of Surface Hydrophilization
Journal of Dental Research,
September 1, 1990;
69(9):
1586 - 1591.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Mitoma, T. Oho, Y. Shimazaki, and T. Koga
Inhibitory Effect of Bovine Milk Lactoferrin on the Interaction between a Streptococcal Surface Protein Antigen and Human Salivary Agglutinin
J. Biol. Chem.,
May 18, 2001;
276(21):
18060 - 18065.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
