This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bobyock, E. Articles by Chernick, W.S. Search for Related Content PubMed PubMed Citation Articles by Bobyock, E. Articles by Chernick, W.S. Social Bookmarking                         What's this?

Vasoactive Intestinal Peptide Interacts with Alpha-adrenergic-, Cholinergic-, and Substance-P-mediated Responses in Rat Parotid and Submandibular Glands

Hahnemann University School of Medicine, Department of Pharmacology, Philadelphia, Pennsylvania 19102

W.S. Chernick

Hahnemann University School of Medicine, Department of Pharmacology, Philadelphia, Pennsylvania 19102

Secretory dose-response curves were obtained with both acetylcholine and phenylephrine treatment in rat parotid and submandibular glands. Vasoactive intestinal peptide (VIP), which produced relatively low volumes of protein-rich saliva in rat salivary glands, also enhanced acetylcholine-, phenylephrine-, and substance-P-mediated fluid and protein secretion when administered in combination with these agents. The specific mechanisms involved in the synergistic actions of VIP with substances such as acetylcholine, phenylephrine, and substance P, which are primarily linked to the production of fluid secretion in rat salivary glands, have yet to be determined.

Journal of Dental Research, Vol. 68, No. 11, 1489-1494 (1989)
DOI: 10.1177/00220345890680110401


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				T. Shintani, C. Hirono, M. Sugita, Y. Iwasa, and Y. Shiba Suppression of carbachol-induced oscillatory Cl- secretion by forskolin in rat parotid and submandibular acinar cells Am J Physiol Gastrointest Liver Physiol, March 1, 2008; 294(3): G738 - G747. [Abstract] [Full Text] [PDF]

				D. A. Brown, J. I. E. Bruce, S. V. Straub, and D. I. Yule cAMP Potentiates ATP-evoked Calcium Signaling in Human Parotid Acinar Cells J. Biol. Chem., September 17, 2004; 279(38): 39485 - 39494. [Abstract] [Full Text] [PDF]

				J. I. E. Bruce, D. I. Yule, and T. J. Shuttleworth Ca2+-dependent Protein Kinase-A Modulation of the Plasma Membrane Ca2+-ATPase in Parotid Acinar Cells J. Biol. Chem., December 6, 2002; 277(50): 48172 - 48181. [Abstract] [Full Text] [PDF]

				A. Tanimura, A. Nezu, Y. Tojyo, and Y. Matsumoto Isoproterenol potentiates alpha -adrenergic and muscarinic receptor-mediated Ca2+ response in rat parotid cells Am J Physiol Cell Physiol, June 1, 1999; 276(6): C1282 - C1287. [Abstract] [Full Text] [PDF]

				J. I. E. Bruce, T. J. Shuttleworth, D. R. Giovannucci, and D. I. Yule Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Parotid Acinar Cells. A MECHANISM FOR THE SYNERGISTIC EFFECTS OF cAMP ON Ca2+ SIGNALING J. Biol. Chem., January 4, 2002; 277(2): 1340 - 1348. [Abstract] [Full Text] [PDF]