Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Chernick, W.
Right arrow Articles by Bradford, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chernick, W.
Right arrow Articles by Bradford, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

5-Hydroxytryptamine Modulation of Rat Parotid Salivary Gland Secretion

W. Chernick

Hahnemann University School of Medicine, Department of Pharmacology, Philadelphia, Pennsylvania 19102

E. Bobyock

Hahnemann University School of Medicine, Department of Pharmacology, Philadelphia, Pennsylvania 19102

P. Bradford

Hahnemann University School of Medicine, Department of Pharmacology, Philadelphia, Pennsylvania 19102

5-Hydroxytryptamine (5-HT) has been reported to produce significant responses in blowfly salivary glands, but little information is available concerning its action on mammalian salivary glands. When 5-HT (0.1 µmol/L to 10 µmol/L) is infused i. a. into anesthetized rats, no salivary secretion is obtained from either parotid or submandibular glands. However, when 5-HT is infused along with a threshold concentration of acetylcholine (0-1 mmol/L), potentiation of parotid secretory response is seen with 5-HT (1 µmol/L, 260% increase; 10 µmol/L, 146% increase). Substance P (0.3 µmol/L) combined with 5-HT (1 µmol/L) also resulted in a potentiation of parotid secretion (160% increase). Protein and calcium concentrations were not altered during such treatments. No potentiation of submandibular secretion was noted. Experiments in vitro with parotid cell aggregates exhibited no potentiation associated with the combined use of 5-HT and carbachol, as measured by amylase secretion and inositol trisphosphate accumulation. The experiments indicate that 5-HT substantially modulates parotid salivary secretion in vivo; however, the in vitro findings suggest that 5-HT does not act directly on surface glandular receptors. The magnitude of the in vivo potentiation could very well implicate circulating or released 5-HT as a physiological modulator of endogenous neurotransmitter action.

Journal of Dental Research, Vol. 68, No. 1, 59-63 (1989)
DOI: 10.1177/00220345890680010901
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JDRHome page
J.T. Turner, D.M. Sullivan, I. Rovira, and J.M. Camden
A Regulatory Role in Mammalian Salivary Glands for 5-Hydroxytryptamine Receptors Coupled to Increased Cyclic AMP Production
Journal of Dental Research, March 1, 1996; 75(3): 935 - 941.
[Abstract] [PDF]

Home page
 JDRHome page
E. Bobyock and W.S. Chernick
Vasoactive Intestinal Peptide Interacts with Alpha-adrenergic-, Cholinergic-, and Substance-P-mediated Responses in Rat Parotid and Submandibular Glands
Journal of Dental Research, November 1, 1989; 68(11): 1489 - 1494.
[Abstract] [PDF]