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Journal of Dental Research
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In vitro Studies on the Potential for Pulpal Cytotoxicity of Glass-Ionomer Cements

W.R. Hume

Department of Dentistry, The University of Adelaide, Adelaide 5000, Australia

G.J. Mount

Department of Dentistry, The University of Adelaide, Adelaide 5000, Australia

Elution samples of glass-ionomer cement were prepared in sterile tissue culture medium either by direct contact between the fluid and standard cement samples or through a layer of human dentin, and then tested for toxicity to cultured mouse fibroblasts (L929). The directly-prepared eluates of the cements were highly cytotoxic, but those prepared through dentin were of either limited or no cytotaxicity. The degree of toxicity of some directly-prepared eluates was reduced by adjustment of the pH to neutrality. It was apparent that dentin reduced the potential for cytotoxicity of glass-ionomer cements to a large degree. Proposed mechanisms for the reduction were limited availability of water at the dentin-cement interface and thus limited dissolution of components, buffering of acid components of the cements by dentin, or other chemical interactions with dentin.

Journal of Dental Research, Vol. 67, No. 6, 915-918 (1988)
DOI: 10.1177/00220345880670060501
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