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Homology of Glucosyltransferase Gene and Protein Sequences from Streptococcus sobrinus and Streptococcus mutans

Dental Research Unit, Royal College of Surgeons of England, Downe, Kent BR6 7JJ, United Kingdom

T. Shiroza

Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA

H.K. Kuramitsu

Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA

J.J. Ferreti

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA

The sequences of glucosyltransferase genes from Streptococcus sobrinus (gtfI) and Streptococcus mutans (gtfB) were compared and show a high degree of homology. There is a 57.7% homology of nucleotides in the genes and a 56. 7% homology of amino acids in the deduced protein sequences. The G + C content for the protein-coding region is 43.6% for S. sobrinus and 41.2% for S. mutans. Internal repeating sequences present in both proteins exhibit some difference in sequence pattern.

Journal of Dental Research, Vol. 67, No. 3, 543-547 (1988)
DOI: 10.1177/00220345880670030401


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