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1H and 13C NMR Studies of the Interaction of Eugenol, Phenol, and Triethyleneglycol Dimethacrylate with Phospholipid Liposomes as a Model System for Odontoblast Membranes

School of Dentistry, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-Ku, Tokyo, 113

Y. Kadoma

Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101, Japan

Y. Komoda

Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101, Japan

To clarify the mechanism of the interaction of eugenol with odontoblast membranes compared with that of phenol and triethyleneglycol dimethacrylate (TEGDMA), we employed dipalmitoylphosphatidylcholine (DPPC) liposomes as a model system for odontoblast membranes. ¹H and ¹³C nuclear magnetic resonance spectroscopy (NMR) was used as the spectroscopic approach in the study of this interaction. No signals of ¹H and ¹³C due to eugenol in the DPPC/eugenol liposomes were observed, indicating that the mobility of eugenol was strongly disturbed by DPPC and that eugenol did not diffuse from the liposomes once it was incorporated. The change in chemical shifts due to phenol between the free state and the DPPC/phenol liposomes was not found, indicating that phenol resides in the aqueous phase or near the surfaces of liposomes, its interaction being markedly weaker than that of eugenol. The signals due to TEGDMA in the DPPC/ TEGDMA liposomes were split into two peaks: a lower-field peak (free TEGDMA) and a higher-field one (membrane-bound TEGDMA). TEGDMA with ethyleneglycol groups seemed to be activated on the liposomes as a surfactant-like agent.

Journal of Dental Research, Vol. 67, No. 11, 1438-1441 (1988)
DOI: 10.1177/00220345880670111501


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