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Dendritic Cells and Macrophages Expressing Class II Antigens in the Normal Rat Incisor Pulp

Department of Endodontics and Oral Diagnosis, Faculty of Odontology, University of Gothenburg and Public Dental Service, Box 33070, S-400 33 Gothenburg, Sweden

G. Bergenholtz

Department of Endodontics, School of Dentistry, University of North Carolina at Chapel Hill, North Carolina 27514, USA

A. Scheynius

Department of Clinical Immunology, Karolinska Institute, Stockholm, Sweden

W. Ambrose

Department of Endodontics, School of Dentistry, University of North Carolina at Chapel Hill, North Carolina 27514, USA

This study has identified and characterized class II (Ia) antigen-expressing cells in the normal rat incisor pulp by immunohistochemistry and flow cytometry. Two types of la-expressing cells occurred: one with a pronounced dendritic appearance located primarily in the periphery of the pulp, and one with morphological characteristics similar to those of macrophages. The latter cells were mainly observed in the central portion of the pulp. A numerical ratio of 1 :4 was established between the two cell types. The existence of la-expressing cells suggests an inherent capacity of the pulp to process and present foreign antigens.

Journal of Dental Research, Vol. 67, No. 10, 1263-1266 (1988)
DOI: 10.1177/00220345880670100301


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