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A Preliminary Report of Long-term Elimination of Detectable Mutans Streptococci in Man

Faculty of Dentistry, University of Toronto, 124 Edward St., Toronto, Ontario, Canada M5G 1G6

J. Brown

Faculty of Dentistry, University of Toronto, 124 Edward St., Toronto, Ontario, Canada M5G 1G6

H.I. Phillips

Faculty of Dentistry, University of Toronto, 124 Edward St., Toronto, Ontario, Canada M5G 1G6

K.H. Chan

Faculty of Dentistry, University of Toronto, 124 Edward St., Toronto, Ontario, Canada M5G 1G6

Application of an antimicrobial varnish to the teeth of 33 adult volunteers resulted in the elimination of detectable mutans streptococci from the saliva of 21 of them for a mean period of 34.6 weeks (range, 4 to 89 weeks) without additional treatment. The mean number of applications of varnish required for elimination was 3.14 (range, 1 to 5). Extensive examination of 10 subjects made free of mutans streptococci on the basis of saliva examination revealed no detectable mutans streptococci in their dental plaque. In 14 of the subjects in whom mutans streptococci were eliminated, they subsequently re-appeared after a mean period of 22.7 weeks (range, 4 to 71 weeks). Four out of the five recurrences that were treated were eliminated with only one additional varnish application. The treatment failed to provide long-term elimination of detectable mutans streptococci in 12 of the 33 treated subjects. No serious adverse reactions were observed in any of the treated subjects. The results indicate that it is possible to eliminate mutans streptococci from man in a safe and effective manner.

Journal of Dental Research, Vol. 67, No. 1, 9-14 (1988)
DOI: 10.1177/00220345880670011801


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