This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Jones, C.L. Articles by Van Der Ouderaa, F. Search for Related Content PubMed PubMed Citation Articles by Jones, C.L. Articles by Van Der Ouderaa, F. Social Bookmarking                         What's this?

The Effect of Long-term Use of a Dentifrice Containing Zinc Citrate and a Non-ionic Agent on the Oral Flora

Unilever Research, Gibbs Dental Division, Port Sunlight Laboratory, Merseyside L63 3JW, United Kingdom

J.A. Ritchie

Unilever Research, Gibbs Dental Division, Port Sunlight Laboratory, Merseyside L63 3JW, United Kingdom

P.D. Marsh

Bacterial Metabolism Research Laboratory, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury SP4 OKG, United Kingdom

F. Van Der Ouderaa

Unilever Research, Gibbs Dental Division, Port Sunlight Laboratory, Merseyside L63 3JW, United Kingdom

The effect on the oral ecology of daily use, for seven months, of a dentifrice containing 0.5% (w/w) zinc citrate and a non-ionic agent, i.e., 0.2% (wlw) Triclosan (2,4,4' -trichloro-2' -hydroxydiphenyl ether), has been monitored on 13 adult volunteers. Plaque and saliva were sampled monthly and the bacterial flora analyzed. Twenty-six volunteers used a placebo dentifrice as part of their normal oral hygiene for four months to establish the baseline microbial flora. The volunteers were then split into two equal groups: One group continued to use the placebo dentifrice; the other used the dentifrice containing zinc citrate and Triclosan. There was no evidence that seven months' use of a dentifrice containing 0.5% zinc citrate and 0.2% Triclosan caused shifts in the oral microbial ecology, nor was there any evidence of developing bacterial resistance to Triclosan.

Journal of Dental Research, Vol. 67, No. 1, 46-50 (1988)
DOI: 10.1177/00220345880670010901


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. J. McBain, R. G. Ledder, P. Sreenivasan, and P. Gilbert Selection for high-level resistance by chronic triclosan exposure is not universal J. Antimicrob. Chemother., May 1, 2004; 53(5): 772 - 777. [Abstract] [Full Text] [PDF]

				A. J. McBain, R. G. Bartolo, C. E. Catrenich, D. Charbonneau, R. G. Ledder, and P. Gilbert Effects of Triclosan-Containing Rinse on the Dynamics and Antimicrobial Susceptibility of In Vitro Plaque Ecosystems Antimicrob. Agents Chemother., November 1, 2003; 47(11): 3531 - 3538. [Abstract] [Full Text] [PDF]

				D.J. Bradshaw, P.D. Marsh, G.K. Watson, and D. Cummins The Effects of Triclosan and Zinc Citrate, Alone and in Combination, on a Community of Oral Bacteria Grown in vitro Journal of Dental Research, January 1, 1993; 72(1): 25 - 30. [Abstract] [PDF]

				P.D. Marsh Microbiological Aspects of the Chemical Control of Plaque and Gingivitis Journal of Dental Research, July 1, 1992; 71(7): 1431 - 1438. [Abstract] [PDF]