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Intra-oral Effects on Acid-softened Enamel of NaF Lozenges Administered in Divided Daily Doses

Department of Pediatric Dentistry, Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109

J.W. Clark

Department of Pediatric Dentistry, Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109

J. Arnold

Department of Pediatric Dentistry, Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109

F.G. More

Department of Pediatric Dentistry, Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109

D. Merrill

Department of Pediatric Dentistry, Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109

C.J. Kowalski

Biostatistic Unit, Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109

The purpose of this investigation was to study the intra-oral effects of multiple daily applications of NaF lozenges upon acid-softened enamel. Bovine enamel slabs were softened with 0.1 mol/L lactate buffer at pH 4.0 for 14 hrs and subsequently mounted in a mandibular removable Hawley appliance. Control slabs were worn for seven days by eight adult male subjects who brushed their natural dentition daily with a fluoride-free dentifrice. Test slabs were exposed to one 0.55-mg NaF lozenge (0.25 mg F) 4x/day for seven days and the natural dentition brushed with a fluoride-free dentifrice. The efficacy of 0.25-mg F lozenges used 4x/day over that of a 1-mg F lozenge administered 1x/day was established by a pilot study with two subjects. Microhardness testing was performed after intra-oral exposure (IOE) and following immersion in 0.01 mol/L lactate buffer containing Ca and P04 for 24 hrs at a pH of 4.0. Fluoride uptake was measured on separate control and test slabs after KOH wash and after acid-resistance-testing (ART). Recovery of microhardness following IOE was 40.9% for controls and 53.9% for treated slabs, while control slabs retained 1.3% resistance to ART, compared with 25.6% for test slabs. The F content of the control slabs was significantly less than that of lozenge-treated and lozenge-treated-ART slabs throughout the depth of the lesion. The F content of the lozenge-treated-ART slabs was significantly less than that of the lozenge-treated slabs only at the 0-5-µm depth. The NaF lozenge-treated enamel lesions demonstrated both significantly greater rehardening and F uptake than did the untreated control enamel lesions.

Journal of Dental Research, Vol. 66, No. 5, 1020-1024 (1987)
DOI: 10.1177/00220345870660050501


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