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Effects of Variations in pH and Hypothiocyanite Concentrations on S. mutans Glucose Metabolism

B. Mansson-Rahemtulla

University of Alabama at Birmingham, Birmingham, Alabama 35294

D.C. Baldone

University of Alabama at Birmingham, Birmingham, Alabama 35294

K.M. Pruitt

University of Alabama at Birmingham, Birmingham, Alabama 35294

F. Rahemtulla

University of Alabama at Birmingham, Birmingham, Alabama 35294

Hypothiocyanous acid (HOSCN) and hypothiocyanite (OSCN-) were generated by the antibody-independent salivary peroxidase (SP) system. The metabolism of Streptococcus mutans NCTC 10449 was examined by uniformly labeled glucose incorporation studies. We found that the SP-system causes a pH-dependent inhibition of 14C-labeled glucose uptake, and that the effects of HOSCN/OSCN- are bacteriostatic. The results also showed that, at low pH, bacteria required more time to recover fully from HOSCN/OSCN- inhibition. When control experiments were performed in the absence of HOSCN/OSCN-, but the pH was varied, we found a positive correlation between pH and the rate of 14C-glucose incorporation. The results also showed that pH did not affect the maximum incorporation of 14C-glucose, demonstrating that S. mutans can adapt to pH changes in the environment. Based on the data obtained, we postulate that the antibody-independent SP system plays an important role in the regulation of the metabolism of oral streptococci.

Journal of Dental Research, Vol. 66, No. 2, 486-491 (1987)
DOI: 10.1177/00220345870660021701
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