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Evaluation of Biochemical Validation Measures in Determination of Smoking Status

Indiana University School of Dentistry, Oral Health Research Institute, 415 North Lansing Street

B.P. Katz

Indiana University School of Medicine, Regenstrief Institute for Health Care, 1001 West 10th Street, Indianapolis, Indiana 46202

B.L. Olson

Indiana University School of Dentistry, Oral Health Research Institute, 415 North Lansing Street

C.A. Drook

Indiana University School of Dentistry, Oral Health Research Institute, 415 North Lansing Street

S.J. Cohen

Indiana University School of Medicine, Regenstrief Institute for Health Care, 1001 West 10th Street, Indianapolis, Indiana 46202

This study was designed to evaluate the use of salivary cotinine, salivary thiocyanate, and expired-air carbon monoxide as biochemical validation measures for assessing the smoking status of adults. The participants were 20 known non-smokers plus 216 admitted smokers and 102 proclaimed quitters participating in a clinical trial of approaches to facilitate smoking cessation. Conventional analytical procedures were utilized. By use of data from known non-smokers and admitted smokers, the sensitivity and specificity of the validation measures were as follows: salivary cotinine, 99% and 100%; expired-air carbon monoxide, 96% and 100%; and salivary thiocyanate, 67% and 95%, respectively. The salivary cotinine and expired-air carbon monoxide tests confirmed smoking cessation for 55% and 74%, respectively, of the proclaimed quitters. The length of time since quitting was significantly related to the results observed with the latter measures. Consideration of these observations along with various practical factors suggests that expired-air carbon monoxide assays may be the validation measure of choice for most clinical trials.

Journal of Dental Research, Vol. 66, No. 10, 1597-1601 (1987)
DOI: 10.1177/00220345870660101801


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