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Effects of pH on Expression of Sodium Fluoride Resistance in Streptococcus mutans

Department of Botany and Microbiology, SCEN-401, University of Arkansas, Fayetteville, Arkansas 72701

T.A. Kral

Department of Botany and Microbiology, SCEN-401, University of Arkansas, Fayetteville, Arkansas 72701

Stable fluoride-resistant mutants of Streptococcus mutans GS-5 were isolated on Todd-Hewitt agar by a step-wise selection procedure. Resistance is defined here as the ability to form colonies in 48 hr. First-step mutants demonstrated six different levels of resistance, ranging from 400 to 1000 µg/mL sodium fluoride. Second-step mutants demonstrated two levels of resistance, one at 1600 and the highest at 3000 µg/mL sodium fluoride. All mutants (originally isolated at pH 7.2) were tested for fluoride resistance at pH 5 and 6. At these lower pH values, all of the mutants demonstrated resistance to fluoride when compared with the parent strain, but at much-reduced levels.

Journal of Dental Research, Vol. 66, No. 10, 1594-1596 (1987)
DOI: 10.1177/00220345870660101701


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