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Journal of Dental Research
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Immunochemical and Biochemical Studies of Human Enamel Proteins during Neonatal Development

M. Zeichner-David

Laboratory for Developmental Biology, Department of Biochemistry, Andrus Gerontology Center

M. Macdougall

Laboratory for Developmental Biology, Department of Biochemistry, Andrus Gerontology Center

J. Vides

Laboratory for Developmental Biology, Department of Biochemistry, Andrus Gerontology Center

M.L. Snead

Laboratory for Developmental Biology, Department of Biochemistry, Andrus Gerontology Center

H.C. Slavkin

Laboratory for Developmental Biology, Department of Biochemistry, Andrus Gerontology Center

S.B. Turkel

Women's Hospital Los Angeles County-USC Medical Center, University of Southern California, University Park MC-0191, Los Angeles, California 90089-0191

Z. Pavlova

Women's Hospital Los Angeles County-USC Medical Center, University of Southern California, University Park MC-0191, Los Angeles, California 90089-0191

The present communication provides descriptions of the developmental, biochemical, and immunological properties of the human enamel extracellular matrix proteins. We report the isolation and partial characterization of the major human enamel proteins, the production of polyclonal antibodies directed against the human enamelins, and a comparison between the immunogenicity of enamelins and amelogenins from human and mouse enamel extracellular matrices. Our results indicate that although enamelins and amelogenins share some epitopes, each one of these proteins appears to invoke a different degree of immunogenicity.

Journal of Dental Research, Vol. 66, No. 1, 50-56 (1987)
DOI: 10.1177/00220345870660011101
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