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In vivo Effects of a SnF2 Gel on Acid-softened Enamel

Department of Pedodontics, Biostatistics Unit, Dental Research Institute, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109

A. Quiros

Department of Pedodontics, Biostatistics Unit, Dental Research Institute, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109

R.E. Corpron

Department of Pedodontics, Biostatistics Unit, Dental Research Institute, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109

F.G. More

Department of Pedodontics, Biostatistics Unit, Dental Research Institute, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109

C.J. Kowalski

Department of Pedodontics, Biostatistics Unit, Dental Research Institute, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109

The purpose of this investigation was to study the intra-oral rehardening of acid-softened enamel and fluoride uptake from SnF2 gel. Bovine enamel slabs were softened with 0.1 mol/L lactate buffer at pH 4.0 for 14 hrs and then mounted in a mandibular removable Hawley appliance. Control slabs were worn for 96 hrs by seven adult males whose teeth were brushed daily with a fluoride-free dentifrice. Test slabs were exposed once/day to 0.4% SnF2 gel. The gel was swabbed onto the slabs for one minute before being replaced in the mouth unrinsed. The natural dentition was brushed 4x/day with a fluoride-free dentifrice. Microhardness testing was performed after a intra-oral exposure (IOE) and after acid-resistance-testing (ART) following immersion in 0.01 mol/L lactate buffer for 24 hrs at pH of 4.0. Fluoride uptake was measured on separate controls, test slabs, and test slabs after ART, with 0.5 mol/L HClO₄ etches of from 15 to 60 sec. The F content was measured with a F-ion-specific electrode and the phosphate content by spectrophotometry. Following IOE, microhardness recovery was 35.6% for control and 37.9% for test slabs, and control slabs retained 1.4% resistance to acid, as compared with 18.6% for the test slabs. The F content of control slabs was significantly less than that of SnF₂-treated slabs from 5 to 60 µm in depth, and the F content of SnF₂-treated slabs after ART was significantly less at depths of from 5 to 35 µm than that of SnF₂-treated slabs not exposed to ART. Both control and SnF ₂ enamel slabs demonstrated rehardening after IOE, but only SnF ₂-treated enamel retained a significant fraction of that rehardening after ART.

Journal of Dental Research, Vol. 65, No. 5, 698-702 (1986)
DOI: 10.1177/00220345860650051401


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