This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Walsh, L.J. Articles by Savage, N.W. Search for Related Content PubMed PubMed Citation Articles by Walsh, L.J. Articles by Savage, N.W. Social Bookmarking                         What's this?

Oral Mucosal Langerhans Cells Express DR and DQ Antigens

Departments of Social and Preventive Dentistry, and Oral Biology and Oral Surgery

G.J. Seymour

Departments of Social and Preventive Dentistry, and Oral Biology and Oral Surgery

N.W. Savage

University of Queensland Dental School, Turbot Street, Brisbane, QLD 4000, Australia

The expression of the Class II antigens HLA-DR and HLA-DQ in human oral mucosa was examined in health and in the presence of inflammation. DQ antigens were detected on dendritic intra-epithelial cells which expressed the Langerhans cells (LC) phenotype T6+, DR+. In healthy gingiva, DR and DQ were co-expressed on Langerhans cells, whereas in an experimental gingivitis (day 8), more LC expressed DR than DQ. Absolute LC numbers were increased in inflammation. Traumatic ulceration of the buccal mucosa resulted in a decrease in the density of T6-, DR-, and DQ-positive cells. Re-population of migrating and regenerated epithelium was complete 10 days after ulcer induction. Disparity between DR and DQ expression was seen in both normal buccal mucosa and throughout the ulcer healing period. These results are in agreement with the reported sequence of Class II antigen expression on lymphoid cells.

Journal of Dental Research, Vol. 65, No. 3, 390-393 (1986)
DOI: 10.1177/00220345860650030301


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				L.J. Walsh, P.E. Lander, G.J. Seymour, and R.N. Powell In vitro Modulation of T6 Expression on Gingival Langerhans Cells by Interleukin-1 Inhibitors and ETAF Journal of Dental Research, March 1, 1987; 66(3): 766 - 769. [Abstract] [PDF]

				L.J. Walsh, G.J. Seymour, and R.N. Powell Interleukin-1 Modulates T6 Expression on a Putative Intra-epithelial Langerhans Cell Precursor Population Journal of Dental Research, December 1, 1986; 65(12): 1424 - 1426. [Abstract] [PDF]