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Journal of Dental Research
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Production and Characterization of Monoclonal Antibodies to Bacteroides gingivalis

L.G. Simonson

Naval Dental Research Institute, Naval Training Center, Building I-H, Great Lakes, Illinois 60088-5259

B.R. Merrell

Naval Dental Research Institute, Naval Training Center, Building I-H, Great Lakes, Illinois 60088-5259

R.F. Rouse

Naval Dental Research Institute, Naval Training Center, Building I-H, Great Lakes, Illinois 60088-5259

I.L. Shklair

Naval Dental Research Institute, Naval Training Center, Building I-H, Great Lakes, Illinois 60088-5259

The rapid detection of Bacteroides gingivalis by immunological methods using monoclonal antibodies could greatly improve the diagnosis and prognosis of severe periodontal disease in adults. In this study, three distinct hybridomas were produced which secrete monoclonal antibodies to soluble and whole-cell antigen preparations of B. gingivalis. The BGII, V F9/2D hybridoma produced a murine antibody that can detect all of the B. gingivalis isolates studied while never cross-reacting with the other oral microbial antigens tested.Received September 11, 1985 Accepted October 31, 1985

Journal of Dental Research, Vol. 65, No. 2, 95-97 (1986)
DOI: 10.1177/00220345860650021801
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This article has been cited by other articles:


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 JDRHome page
D. Ni Eidhin and C. Mouton
The Lipopolysaccharide of Porphyromonas gingivalis is not Antigenically Cross-reactive with that of Other Species
Journal of Dental Research, March 1, 1994; 73(3): 661 - 670.
[Abstract] [PDF]

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K. Okuda and I. Takazoe
The Role of Bacteroides Gingivalis in Periodontal Disease
Advances in Dental Research, November 1, 1988; 2(2): 260 - 268.
[Abstract] [PDF]