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Enamel Demineralization and the Length of Intra-oral Exposure to Different Concentrations of Glucose or Sucrose

Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

D. Goulet

Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

F. Brudevold

Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

F. Attarzadeh

Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

Six subjects wore intra-oral devices carrying eight bovine enamel blocks which were covered with a layer of S. mutans. They rinsed their mouths for five sec, one min, or multiples of one min with a 5 or 10% glucose (G) solution. Demineralization was measured after 45 min by determining the change in iodide permeability (Ip) of the enamel. In addition, saliva samples, taken at intervals during the test, were analyzed for G, and the time of clearance (t_c ) was calculated. Demineralization scores (Ip) were consistently greater from the 10% than from the 5% G solution. Both solutions produced an increase in Ip with an increase in the rinsing time (t_r). The G remaining in saliva after the rinse did not significantly affect Ip. The Ip scores showed good correlation with the final pH of the S. mutans cell mass, r= -0.77. For each rinse solution, the scores also showed good correlations with t_r (r=0.87 and 0.79) and much weaker correlations with t_r + t_c (r=0.44 and 0.53). Continuous in vitro exposure to 1, 5, or 10% solutions of sucrose (S) in saliva for 30 min or more caused a linear increase in Ip with time with no concentration effects. A linear increase was also observed in vivo when a one-minute mouth-rinse with 10% solution of S was administered every 30 min. The findings indicate that significant demineralization may occur while carbohydrate foods are consumed, and that brushing the teeth or rinsing the mouth after meals may not be as effective against caries as is generally believed.

Journal of Dental Research, Vol. 65, No. 2, 139-145 (1986)
DOI: 10.1177/00220345860650021001


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